- 2004 -2009 Postdoctoral Fellowship : Obesity Research Center and Genome Research Institute, University of Cincinnati (Psychiatry)
- Doctoral Degree: University of Vigo (Biological Sciences)
- : Faculty of Sciences, University of Vigo (Biology)
- Office 513-558-2001
- Email pereztdo@ucmail.uc.edu
Peer Reviewed Publications
El, Kimberley; Douros, Jonathan D; Willard, Francis S; Novikoff, Aaron; Sargsyan, Ashot; Perez-Tilve, Diego; Wainscott, David B; Yang, Bin; Chen, Alex; Wothe, Donald; Coupland, Callum; Tschöp, Mattias H; Finan, Brian; D'Alessio, David A; Sloop, Kyle W; Müller, Timo D; Campbell, Jonathan E 2023. The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets. Nature metabolism, 5 6, 945-954
Knerr, Patrick J; Mowery, Stephanie A; Douros, Jonathan D; Premdjee, Bhavesh; Hjøllund, Karina Rahr; He, Yantao; Kruse Hansen, Ann Maria; Olsen, Anette K; Perez-Tilve, Diego; DiMarchi, Richard D; Finan, Brian 2022. Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice. Molecular metabolism, 63 , 101533
Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego 2022. Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons. Neuroendocrinology, 112 3, 287-297
Quarta, Carmelo; Stemmer, Kerstin; Novikoff, Aaron; Yang, Bin; Klingelhuber, Felix; Harger, Alex; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Baugé, Eric; Campbell, Jonathan E; Capozzi, Megan; Clemmensen, Christoffer; Collden, Gustav; Cota, Perla; Douros, Jon; Drucker, Daniel J; DuBois, Barent; Feuchtinger, Annette; Garcia-Caceres, Cristina; Grandl, Gerald; Hennuyer, Nathalie; Herzig, Stephan; Hofmann, Susanna M; Knerr, Patrick J; Kulaj, Konxhe; Lalloyer, Fanny; Lickert, Heiko; Liskiewicz, Arek; Liskiewicz, Daniela; Maity, Gandhari; Perez-Tilve, Diego; Prakash, Sneha; Sanchez-Garrido, Miguel A; Zhang, Qian; Staels, Bart; Krahmer, Natalie; DiMarchi, Richard D; Tschöp, Matthias H; Finan, Brian; Müller, Timo D 2022. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature metabolism, 4 8, 1071-1083
Yang, Bin; Gelfanov, Vasily M; El, Kimberley; Chen, Alex; Rohlfs, Rebecca; DuBois, Barent; Kruse Hansen, Ann Maria; Perez-Tilve, Diego; Knerr, Patrick J; D'Alessio, David; Campbell, Jonathan E; Douros, Jonathan D; Finan, Brian 2022. Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems. Molecular metabolism, 66 , 101638
Yang, Bin; Gelfanov, Vasily M; Perez-Tilve, Diego; DuBois, Barent; Rohlfs, Rebecca; Levy, Jay; Douros, Jonathan D; Finan, Brian; Mayer, John P; DiMarchi, Richard D 2021. Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists. Journal of medicinal chemistry, 64 8, 4697-4708
Zhang, Qian; Delessa, Challa Tenagne; Augustin, Robert; Bakhti, Mostafa; Colldén, Gustav; Drucker, Daniel J; Feuchtinger, Annette; Caceres, Cristina Garcia; Grandl, Gerald; Harger, Alexandra; Herzig, Stephan; Hofmann, Susanna; Holleman, Cassie Lynn; Jastroch, Martin; Keipert, Susanne; Kleinert, Maximilian; Knerr, Patrick J; Kulaj, Konxhe; Legutko, Beata; Lickert, Heiko; Liu, Xue; Luippold, Gerd; Lutter, Dominik; Malogajski, Emilija; Medina, Marta Tarquis; Mowery, Stephanie A; Blutke, Andreas; Perez-Tilve, Diego; Salinno, Ciro; Sehrer, Laura; DiMarchi, Richard D; Tschöp, Matthias H; Stemmer, Kerstin; Finan, Brian; Wolfrum, Christian; Müller, Timo D 2021. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell metabolism, 33 4, 833-844.e5
Zizzari, Philippe; He, Rongjun; Falk, Sarah; Bellocchio, Luigi; Allard, Camille; Clark, Samantha; Lesté-Lasserre, Thierry; Marsicano, Giovanni; Clemmensen, Christoffer; Perez-Tilve, Diego; Finan, Brian; Cota, Daniela; Quarta, Carmelo 2021. CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity. Diabetes, 70 2, 415-422
Kabotso, Daniel E K; Smiley, David; Mayer, John P; Gelfanov, Vasily M; Perez-Tilve, Diego; DiMarchi, Richard D; Pohl, Nicola L B; Liu, Fa 2020. Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence. Journal of medicinal chemistry, 63 11, 6134-6143
Knerr, Patrick J; Mowery, Stephanie A; Finan, Brian; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D 2020. Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates. Peptides, 125 , 170225
Pan, Jia; Parlee, Sebastian D; Brunel, Florence M; Li, Pengyun; Lu, Wei; Perez-Tilve, Diego; Liu, Fa; Finan, Brian; Kharitonenkov, Alexei; DiMarchi, Richard D 2020. Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21. ACS pharmacology & translational science, 3 5, 978-986
Perez-Tilve, Diego 2020. Glucagon Peptide Family and Adipose Tissue: Not that Intimate, just Acquaintances. Endocrinology, 161 2,
Sorrell, Joyce; Yates, Emily; Rivir, Marita; Woods, Stephen C; Hogenesch, John B; Perez-Tilve, Diego 2020. The central melanocortin system mediates the benefits of time-restricted feeding on energy balance. Physiology & behavior, 227 , 113132
Brunel, Florence M; Mayer, John P; Gelfanov, Vasily M; Zaykov, Alexander N; Finan, Brian; Perez-Tilve, Diego; DiMarchi, Richard D 2019. A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity. ACS chemical biology, 14 8, 1829-1835
Holland, Jenna; Sorrell, Joyce; Yates, Emily; Smith, Kathleen; Arbabi, Shahriar; Arnold, Myrtha; Rivir, Marita; Morano, Rachel; Chen, Jenny; Zhang, Xiang; Dimarchi, Richard; Woods, Stephen C; Sanchez-Gurmaches, Joan; Wohleb, Eric; Perez-Tilve, Diego 2019. A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Cell reports, 27 8, 2399-2410.e6
Mroz, Piotr A; Finan, Brian; Gelfanov, Vasily; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D; Perez-Tilve, Diego 2019. Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism. Molecular metabolism, 20 , 51-62
Müller, T D; Finan, B; Bloom, S R; D'Alessio, D; Drucker, D J; Flatt, P R; Fritsche, A; Gribble, F; Grill, H J; Habener, J F; Holst, J J; Langhans, W; Meier, J J; Nauck, M A; Perez-Tilve, D; Pocai, A; Reimann, F; Sandoval, D A; Schwartz, T W; Seeley, R J; Stemmer, K; Tang-Christensen, M; Woods, S C; DiMarchi, R D; Tschöp, M H 2019. Glucagon-like peptide 1 (GLP-1). Molecular metabolism, 30 , 72-130
Perez-Tilve, Diego 2019. 'Et Tu, Leptin?'. Trends in endocrinology and metabolism: TEM, 30 4, 232-233
Zaykov, Alexander N; Gelfanov, Vasily M; Perez-Tilve, Diego; Finan, Brian; DiMarchi, Richard D 2019. Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice. Peptides, 120 , 170116
Agrawal, Archita; Parlee, Sebastian; Perez-Tilve, Diego; Li, Pengyun; Pan, Jia; Mroz, Piotr A; Kruse Hansen, Ann Maria; Andersen, Birgitte; Finan, Brian; Kharitonenkov, Alexei; DiMarchi, Richard D 2018. Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. Molecular metabolism, ,
Kim, Teayoun; Holleman, Cassie L; Nason, Shelly; Arble, Deanna M; Ottaway, Nickki; Chabenne, Joseph; Loyd, Christine; Kim, Jeong-A; Sandoval, Darleen; Drucker, Daniel J; DiMarchi, Richard; Perez-Tilve, Diego; Habegger, Kirk M 2018. Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents. Diabetes, 67 11, 2157-2166
Kim, Teayoun; Nason, Shelly; Holleman, Cassie; Pepin, Mark; Wilson, Landon; Berryhill, Taylor F; Wende, Adam R; Steele, Chad; Young, Martin E; Barnes, Stephen; Drucker, Daniel J; Finan, Brian; DiMarchi, Richard; Perez-Tilve, Diego; Tschöp, Matthias; Habegger, Kirk M 2018. Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes, 67 9, 1773-1782
Mahbod, Parinaz; Smith, Eric P; Fitzgerald, Maureen E; Morano, Rachel L; Packard, Benjamin A; Ghosal, Sriparna; Scheimann, Jessie R; Perez-Tilve, Diego; Herman, James P; Tong, Jenny 2018. Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice. Endocrinology, 159 1, 388-399
Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620
Rivero-Gutierrez, Belen; Haller, April; Holland, Jenna; Yates, Emily; Khrisna, Radha; Habegger, Kirk; Dimarchi, Richard; D'Alessio, David; Perez-Tilve, Diego 2018. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Molecular metabolism, 17 , 28-38
Ryan, Karen K; Packard, Amy E B; Larson, Karlton R; Stout, Jayna; Fourman, Sarah M; Thompson, Abigail M K; Ludwick, Kristen; Habegger, Kirk M; Stemmer, Kerstin; Itoh, Nobuyuki; Perez-Tilve, Diego; Tschöp, Matthias H; Seeley, Randy J; Ulrich-Lai, Yvonne M 2018. Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21. Endocrinology, 159 1, 400-413
Knerr, Patrick J; Finan, Brian; Gelfanov, Vasily; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D 2017. Optimization of peptide-based polyagonists for treatment of diabetes and obesity. Bioorganic & medicinal chemistry, ,
Perez-Tilve, Diego 2017. Novel Hypothalamic Mechanisms in the Pathophysiological Control of Body Weight and Metabolism. Endocrinology, 158 5, 1085-1094
Quarta, Carmelo; Clemmensen, Christoffer; Zhu, Zhimeng; Yang, Bin; Joseph, Sini S; Lutter, Dominik; Yi, Chun-Xia; Graf, Elisabeth; García-Cáceres, Cristina; Legutko, Beata; Fischer, Katrin; Brommage, Robert; Zizzari, Philippe; Franklin, Bernardo S; Krueger, Martin; Koch, Marco; Vettorazzi, Sabine; Li, Pengyun; Hofmann, Susanna M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Lickert, Heiko; Strom, Tim M; Gailus-Durner, Valerie; Bechmann, Ingo; Perez-Tilve, Diego; Tuckermann, Jan; Hrab? de Angelis, Martin; Sandoval, Darleen; Cota, Daniela; Latz, Eicke; Seeley, Randy J; Müller, Timo D; DiMarchi, Richard D; Finan, Brian; Tschöp, Matthias H 2017. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell metabolism, 26 4, 620-632.e6
Finan, Brian; Clemmensen, Christoffer; Zhu, Zhimeng; Stemmer, Kerstin; Gauthier, Karine; Müller, Luisa; De Angelis, Meri; Moreth, Kristin; Neff, Frauke; Perez-Tilve, Diego; Fischer, Katrin; Lutter, Dominik; Sánchez-Garrido, Miguel A; Liu, Peng; Tuckermann, Jan; Malehmir, Mohsen; Healy, Marc E; Weber, Achim; Heikenwalder, Mathias; Jastroch, Martin; Kleinert, Maximilian; Jall, Sigrid; Brandt, Sara; Flamant, Frédéric; Schramm, Karl-Werner; Biebermann, Heike; Döring, Yvonne; Weber, Christian; Habegger, Kirk M; Keuper, Michaela; Gelfanov, Vasily; Liu, Fa; Köhrle, Josef; Rozman, Jan; Fuchs, Helmut; Gailus-Durner, Valerie; Hrab? de Angelis, Martin; Hofmann, Susanna M; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard; Müller, Timo D 2016. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell, 167 3, 843-857.e14
Finan, Brian; Müller, Timo D; Clemmensen, Christoffer; Perez-Tilve, Diego; DiMarchi, Richard D; Tschöp, Matthias H 2016. Reappraisal of GIP Pharmacology for Metabolic Diseases. Trends in molecular medicine, 22 5, 359-76
Kabra, Dhiraj G; Pfuhlmann, Katrin; García-Cáceres, Cristina; Schriever, Sonja C; Casquero García, Veronica; Kebede, Adam Fiseha; Fuente-Martin, Esther; Trivedi, Chitrang; Heppner, Kristy; Uhlenhaut, N Henriette; Legutko, Beata; Kabra, Uma D; Gao, Yuanqing; Yi, Chun-Xia; Quarta, Carmelo; Clemmensen, Christoffer; Finan, Brian; Müller, Timo D; Meyer, Carola W; Paez-Pereda, Marcelo; Stemmer, Kerstin; Woods, Stephen C; Perez-Tilve, Diego; Schneider, Robert; Olson, Eric N; Tschöp, Matthias H; Pfluger, Paul T 2016. Hypothalamic leptin action is mediated by histone deacetylase 5. Nature communications, 7 , 10782
Loyd, Christine; Magrisso, I Jack; Haas, Michael; Balusu, Sowmya; Krishna, Radha; Itoh, Nobuyuki; Sandoval, Darleen A; Perez-Tilve, Diego; Obici, Silvana; Habegger, Kirk M 2016. Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding. Journal of applied physiology (Bethesda, Md. : 1985), 121 3, 687-98
Mroz, Piotr A; Perez-Tilve, Diego; Liu, Fa; Gelfanov, Vasily; DiMarchi, Richard D; Mayer, John P 2016. Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization. Journal of medicinal chemistry, 59 17, 8061-7
Mroz, Piotr A; Perez-Tilve, Diego; Liu, Fa; Mayer, John P; DiMarchi, Richard D 2016. Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon. ACS chemical biology, 11 12, 3412-3420
Raab, Susanne; Wang, Haiyan; Uhles, Sabine; Cole, Nadine; Alvarez-Sanchez, Ruben; Künnecke, Basil; Ullmer, Christoph; Matile, Hugues; Bedoucha, Marc; Norcross, Roger D; Ottaway-Parker, Nickki; Perez-Tilve, Diego; Conde Knape, Karin; Tschöp, Matthias H; Hoener, Marius C; Sewing, Sabine 2016. Incretin-like effects of small molecule trace amine-associated receptor 1 agonists. Molecular metabolism, 5 1, 47-56
Sánchez-Garrido, Miguel Angel; Habegger, Kirk M; Clemmensen, Christoffer; Holleman, Cassie; Müller, Timo D; Perez-Tilve, Diego; Li, Pengyun; Agrawal, Archita S; Finan, Brian; Drucker, Daniel J; Tschöp, Matthias H; DiMarchi, Richard D; Kharitonenkov, Alexei 2016. Fibroblast activation protein (FAP) as a novel metabolic target. Molecular metabolism, 5 10, 1015-24
Tschöp, Matthias H; Finan, Brian; Clemmensen, Christoffer; Gelfanov, Vasily; Perez-Tilve, Diego; Müller, Timo D; DiMarchi, Richard D 2016. Unimolecular Polypharmacy for Treatment of Diabetes and Obesity. Cell metabolism, 24 1, 51-62
Arble, Deanna M; Holland, Jenna; Ottaway, Nickki; Sorrell, Joyce; Pressler, Joshua W; Morano, Rachel; Woods, Stephen C; Seeley, Randy J; Herman, James P; Sandoval, Darleen A; Perez-Tilve, Diego 2015. The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology, 156 5, 1685-91
Finan, Brian; Yang, Bin; Ottaway, Nickki; Smiley, David L; Ma, Tao; Clemmensen, Christoffer; Chabenne, Joe; Zhang, Lianshan; Habegger, Kirk M; Fischer, Katrin; Campbell, Jonathan E; Sandoval, Darleen; Seeley, Randy J; Bleicher, Konrad; Uhles, Sabine; Riboulet, William; Funk, Jürgen; Hertel, Cornelia; Belli, Sara; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; Drucker, Daniel J; Gelfanov, Vasily; Pfluger, Paul T; Müller, Timo D; Perez-Tilve, Diego; DiMarchi, Richard D; Tschöp, Matthias H 2015. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nature medicine, 21 1, 27-36
Heppner, Kristy M; Marks, Sarah; Holland, Jenna; Ottaway, Nickki; Smiley, David; Dimarchi, Richard; Perez-Tilve, Diego 2015. Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice. Diabetologia, 58 9, 2124-32
Heppner, Kristy M; Perez-Tilve, Diego 2015. GLP-1 based therapeutics: simultaneously combating T2DM and obesity. Frontiers in neuroscience, 9 , 92
Müller, T D; Nogueiras, R; Andermann, M L; Andrews, Z B; Anker, S D; Argente, J; Batterham, R L; Benoit, S C; Bowers, C Y; Broglio, F; Casanueva, F F; D'Alessio, D; Depoortere, I; Geliebter, A; Ghigo, E; Cole, P A; Cowley, M; Cummings, D E; Dagher, A; Diano, S; Dickson, S L; Diéguez, C; Granata, R; Grill, H J; Grove, K; Habegger, K M; Heppner, K; Heiman, M L; Holsen, L; Holst, B; Inui, A; Jansson, J O; Kirchner, H; Korbonits, M; Laferrère, B; LeRoux, C W; Lopez, M; Morin, S; Nakazato, M; Nass, R; Perez-Tilve, D; Pfluger, P T; Schwartz, T W; Seeley, R J; Sleeman, M; Sun, Y; Sussel, L; Tong, J; Thorner, M O; van der Lely, A J; van der Ploeg, L H T; Zigman, J M; Kojima, M; Kangawa, K; Smith, R G; Horvath, T; Tschöp, M H 2015. Ghrelin. Molecular metabolism, 4 6, 437-60
Ottaway, Nickki; Mahbod, Parinaz; Rivero, Belen; Norman, Lee Ann; Gertler, Arieh; D'Alessio, David A; Perez-Tilve, Diego 2015. Diet-induced obese mice retain endogenous leptin action. Cell metabolism, 21 6, 877-82
Pfluger, Paul T; Kabra, Dhiraj G; Aichler, Michaela; Schriever, Sonja C; Pfuhlmann, Katrin; García, Verónica Casquero; Lehti, Maarit; Weber, Jon; Kutschke, Maria; Rozman, Jan; Elrod, John W; Hevener, Andrea L; Feuchtinger, Annette; Hrab? de Angelis, Martin; Walch, Axel; Rollmann, Stephanie M; Aronow, Bruce J; Müller, Timo D; Perez-Tilve, Diego; Jastroch, Martin; De Luca, Maria; Molkentin, Jeffery D; Tschöp, Matthias H 2015. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell metabolism, 22 5, 838-50
Trivedi, Chitrang; Shan, Xiaoye; Tung, Yi-Chun Loraine; Kabra, Dhiraj; Holland, Jenna; Amburgy, Sarah; Heppner, Kristy; Kirchner, Henriette; Yeo, Giles S H; Perez-Tilve, Diego 2015. Tachykinin-1 in the central nervous system regulates adiposity in rodents. Endocrinology, 156 5, 1714-23
Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., Garcia-Caceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschop, M. H., and Yi, C. X. 2014. Hormones and diet, but not body weight, control hypothalamic microglial activity Glia , 62, 17-25
Gao, Yuanqing; Ottaway, Nickki; Schriever, Sonja C; Legutko, Beata; García-Cáceres, Cristina; de la Fuente, Esther; Mergen, Clarita; Bour, Susanne; Thaler, Joshua P; Seeley, Randy J; Filosa, Jessica; Stern, Javier E; Perez-Tilve, Diego; Schwartz, Michael W; Tschöp, Matthias H; Yi, Chun-Xia 2014. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia, 62 1, 17-25
Habegger, K. M., Heppner, K. M., Amburgy, S. E., Ottaway, N., Holland, J., Raver, C., Bartley, E., Muller, T. D., Pfluger, P. T., Berger, J., Toure, M., Benoit, S. C., Dimarchi, R. D., Perez-Tilve, D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. 2014. GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats. Diabetes., 63, 505-13
Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; Dimarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2014. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes, 63 2, 505-13
Heppner, K. M., Piechowski, C. L., Muller, A.,D. A., and Perez-Tilve, D. Ottaway, N., Sisley, S., Smiley, D. L., Habegger, K. M., Pfluger, P. T., Dimarchi, R., Biebermann, H., Tschop, M. H., Sandoval, 2014. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes., 63, 122-131
Heppner, Kristy M; Piechowski, Carolin L; Müller, Anne; Ottaway, Nickki; Sisley, Stephanie; Smiley, David L; Habegger, Kirk M; Pfluger, Paul T; Dimarchi, Richard; Biebermann, Heike; Tschöp, Matthias H; Sandoval, Darleen A; Perez-Tilve, Diego 2014. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes, 63 1, 122-31
Smith, Eric P; An, Zhibo; Wagner, Constance; Lewis, Alfor G; Cohen, Eric B; Li, Bailing; Mahbod, Parinaz; Sandoval, Darleen; Perez-Tilve, Diego; Tamarina, Natalia; Philipson, Louis H; Stoffers, Doris A; Seeley, Randy J; D'Alessio, David A 2014. The role of ? cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. Cell metabolism, 19 6, 1050-7
Finan, B., Ma, T., Ottaway, N., Muller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., Lockie, S. H., Smiley, D. L., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D. J., Pfluger, P. T., Perez-Tilve, D., Gidda, J., Vignati, L., Zhang, L., Hauptman, J. B., Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, E., Sebokova, E., Conde-Knape, K., Konkar, A., DiMarchi, R. D., and Tschop, M. H. 2013. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Science translational medicine, 5, 209-151
Gadang, V., Kohli, R., Myronovych, A., Hui, D. Y., Perez-Tilve, D., and Jaeschke, A. 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism , 305, 549-556
Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism, 305 4, E549-56
Habegger, K. M., Al-Massadi, O., Heppner, K. M., Myronovych, A., Holland, J., Berger, J., Yi, C. X., Gao, Y., Lehti, M., Ottaway, N., Amburgy, S., Raver, C., Muller, T. D., Pfluger, P. T., Kohli, R., Perez-Tilve, D., Seeley, R. J., and Tschop, M. H. 2013. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut , ,
Habegger, K. M., Kirchner, H., Yi, C. X., Heppner, K. M., Sweeney, D., Ottaway, N., Holland, J., Amburgy, S., Raver, C., Krishna, R., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Obici, S., DiMarchi, R. D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. 2013. GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes., 62, 3261-3267
Habegger, K. M., Stemmer, K., Cheng, C., Muller, T. D., Heppner, K. M., Ottaway, N., Holland, J., Hembree, J. L., Smiley, D., Gelfanov, V., Krishna, R., Arafat, A. M., Konkar,A., Belli, S., Kapps, M., Woods, S. C., Hofmann, S. M., D'Alessio, D., Pfluger, P. T., Perez-Tilve, D., Seeley, R. J., Konishi, M., Itoh, N., Kharitonenkov, A., Spranger, J., DiMarchi, R. D., and Tschop, M. H. 2013. Fibroblast growth factor 21 mediates specific glucagon actions Diabetes, 62, 1453-1463
Habegger, Kirk M; Al-Massadi, Omar; Heppner, Kristy M; Myronovych, Andriy; Holland, Jenna; Berger, Jose; Yi, Chun-Xia; Gao, Yuanging; Lehti, Maarit; Ottaway, Nickki; Amburgy, Sarah; Raver, Christine; Müller, Timo D; Pfluger, Paul T; Kohli, Rohit; Perez-Tilve, Diego; Seeley, Randy J; Tschöp, Matthias H 2013. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut, ,
Habegger, Kirk M; Kirchner, Henriette; Yi, Chun-Xia; Heppner, Kristy M; Sweeney, Dan; Ottaway, Nickki; Holland, Jenna; Amburgy, Sarah; Raver, Christine; Krishna, Radhakrishna; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Obici, Silvana; DiMarchi, Richard D; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2013. GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes, 62 9, 3261-7
Habegger, Kirk M; Stemmer, Kerstin; Cheng, Christine; Müller, Timo D; Heppner, Kristy M; Ottaway, Nickki; Holland, Jenna; Hembree, Jazzminn L; Smiley, David; Gelfanov, Vasily; Krishna, Radha; Arafat, Ayman M; Konkar, Anish; Belli, Sara; Kapps, Martin; Woods, Stephen C; Hofmann, Susanna M; D'Alessio, David; Pfluger, Paul T; Perez-Tilve, Diego; Seeley, Randy J; Konishi, Morichika; Itoh, Nobuyujki; Kharitonenkov, Alexei; Spranger, Joachim; DiMarchi, Richard D; Tschöp, Matthias H 2013. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes, 62 5, 1453-63
Heppner, K M; Müller, T D; Kirchner, H; Perez-Tilve, D; Pfluger, P T; Tschöp, M H; Hofmann, S M 2013. The role of ghrelin-octanoyl-acyl-transferase in thermoregulation. Journal of endocrinological investigation, 36 3, 180-4
Heppner, K. M., Muller, T. D., Kirchner, H., Perez-Tilve, D., Pfluger, P. T., Tschop, M. H., and Hofmann, S. M. 2013. The role of ghrelin-octanoyl-acyl-transferase in thermoregulation Journal of endocrinological investigation , 36, 180-184
Lim, C. T., Kola, B., Feltrin, D., Perez-Tilve, D., Tschop, M. H., Grossman, A. B., and Korbonits, M. 2013. Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. Molecular and cellular endocrinology, 365, 303-308
Muller, T. D., Lee, S. J., Jastroch, M., Kabra, D., Stemmer, K., Aichler, M., Abplanalp, B., Ananthakrishnan, G., Bhardwaj, N., Collins, S., Divanovic, S., Endele, M., Finan, B., Gao, Y., Habegger, K. M., Hembree, J., Heppner, K. M., Hofmann, S., Holland, J., Kuchler, D., Kutschke, M., Krishna, R., Lehti, M., Oelkrug, R., Ottaway, N., Perez-Tilve, D., Raver, C., Walch, A. K., Schriever, S. C., Speakman, J., Tseng, Y. H., Diaz-Meco, M., Pfluger, P. T., Moscat, J., and Tschop, M. H. 2013. p62 links beta-adrenergic input to mitochondrial function and thermogenesis. The Journal of clinical investigation, 123, 469-478
Muller, T. D., Muller, A., Yi, C. X., Habegger, K. M., Meyer, C. W., Gaylinn, B. D., Finan, B., Heppner, K., Trivedi, C., Bielohuby, M., Abplanalp, W., Meyer, F., Piechowski, C. L., Pratzka, J., Stemmer, K., Holland, J., Hembree, J., Bhardwaj, N., Raver, C., Ottaway, N., Krishna, R., Sah, R., Sallee, F. R., Woods, S. C., Perez-Tilve, D., Bidlingmaier, M., Thorner, M. O., Krude, H., Smiley, D., DiMarchi, R., Hofmann, S., Pfluger, P. T., Kleinau, G., Biebermann, H., and Tschop, M. H 2013. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms Nature communications, 4, 1968
Ward, B. P., Ottaway, N. L., Perez-Tilve, D., Ma, D., Gelfanov, V. M., Tschop, M. H., and Dimarchi, R. D 2013. Peptide lipidation stabilizes structure to enhance biological function. Molecular metabolism, 2, 468-479
Wilson-Perez, H. E., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D., Drucker, D. J., Perez-Tilve, D., and Seeley, R. J. 2013. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes., 62, 2380-2385
Wilson-Pérez, Hilary E; Chambers, Adam P; Ryan, Karen K; Li, Bailing; Sandoval, Darleen A; Stoffers, Doris; Drucker, Daniel J; Pérez-Tilve, Diego; Seeley, Randy J 2013. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes, 62 7, 2380-5
abegger, K. M., Matzke, D., Ottaway, N., Hembree, J., Holland, J., Raver, C., Mansfeld, J., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Lee, S. J., Diaz-Meco, M., Moscat, J., Leitges, M., Tschop, M. H., and Hofmann, S. M. 2012. Role of adipose and hepatic atypical protein kinase C lambda (PKClambda) in the development of obesity and glucose intolerance. Adipocyte, 1, 203-214
Finan, B., Yang, B., Ottaway, N., Stemmer, K., Muller, T. D., Yi, C. X., Habegger, K., Schriever, S. C., Garcia-Caceres, C., Kabra, D. G., Hembree, J., Holland, J., Raver, C., Seeley, R. J., Hans, W., Irmler, M., Beckers, J., de Angelis, M. H., Tiano, J. P., Mauvais-Jarvis, F., Perez-Tilve, D., Pfluger, P., Zhang, L., Gelfanov, V., DiMarchi, R. D., and Tschop, M. H. 2012. Targeted estrogen delivery reverses the metabolic syndrome. Nature medicine, 18, 1847-1856
Habegger, Kirk M; Matzke, Daniela; Ottaway, Nickki; Hembree, Jazzminn; Holland, Jenna; Raver, Christine; Mansfeld, Johannes; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Lee, Sang Jun; Diaz-Meco, Maria; Moscat, Jorge; Leitges, Michael; Tschöp, Matthias H; Hofmann, Susanna M 2012. Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance. Adipocyte, 1 4, 203-214
Heppner, K. M., Chaudhary, N., Muller, T. D., Kirchner, H., Habegger, K. M., Ottaway, N., Smiley, D. L., Dimarchi, R., Hofmann, S. M., Woods, S. C., Sivertsen, B., Holst, B., Pfluger, P. T., Perez-Tilve, D., and Tschop, M. H. 2012. Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology , 153, 4687-4695
Heppner, Kristy M; Chaudhary, Nilika; Müller, Timo D; Kirchner, Henriette; Habegger, Kirk M; Ottaway, Nickki; Smiley, David L; Dimarchi, Richard; Hofmann, Susanna M; Woods, Stephen C; Sivertsen, Bjørn; Holst, Birgitte; Pfluger, Paul T; Perez-Tilve, Diego; Tschöp, Matthias H 2012. Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology, 153 10, 4687-95
Kirchner, H., Hofmann, S. M., Fischer-Rosinsky, A., Hembree, J., Abplanalp, W., Ottaway, N., Donelan, E., Krishna, R., Woods, S. C., Muller, T. D., Spranger, J., Perez-Tilve, D., Pfluger, P. T., Tschop, M. H., and Habegger, K. M. 2012. Caloric restriction chronically impairs metabolic programming in mice. Diabetes., 61, 2734-2742
Kirchner, Henriette; Hofmann, Susanna M; Fischer-Rosinský, Antje; Hembree, Jazzminn; Abplanalp, William; Ottaway, Nickki; Donelan, Elizabeth; Krishna, Radha; Woods, Stephen C; Müller, Timo D; Spranger, Joachim; Perez-Tilve, Diego; Pfluger, Paul T; Tschöp, Matthias H; Habegger, Kirk M 2012. Caloric restriction chronically impairs metabolic programming in mice. Diabetes, 61 11, 2734-42
Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschop, M. H., and Perez-Tilve, D. 2012. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling Diabetes., 61, 2753-2762
Lockie, Sarah H; Heppner, Kristy M; Chaudhary, Nilika; Chabenne, Joseph R; Morgan, Donald A; Veyrat-Durebex, Christelle; Ananthakrishnan, Gayathri; Rohner-Jeanrenaud, Françoise; Drucker, Daniel J; DiMarchi, Richard; Rahmouni, Kamal; Oldfield, Brian J; Tschöp, Matthias H; Perez-Tilve, Diego 2012. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes, 61 11, 2753-62
Muller, T. D., Sullivan, L. M., Habegger, K., Yi, C. X., Kabra, D., Grant, E., Ottaway, N., Krishna, R., Holland, J., Hembree, J., Perez-Tilve, D., Pfluger, P. T., DeGuzman, M. J., Siladi, M. E., Kraynov, V. S., Axelrod, D. W., DiMarchi, R., Pinkstaff, J. K., and Tschop, M. H. 2012. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21 Journal of peptide science : an official publication of the European Peptide Society , 18, 383-393
Müller, Timo D; Sullivan, Lorraine M; Habegger, Kirk; Yi, Chun-Xia; Kabra, Dhiraj; Grant, Erin; Ottaway, Nickki; Krishna, Radha; Holland, Jenna; Hembree, Jazzminn; Perez-Tilve, Diego; Pfluger, Paul T; DeGuzman, Michael J; Siladi, Marc E; Kraynov, Vadim S; Axelrod, Douglas W; DiMarchi, Richard; Pinkstaff, Jason K; Tschöp, Matthias H 2012. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. Journal of peptide science : an official publication of the European Peptide Society, 18 6, 383-93
Stemmer, K., Perez-Tilve, D., Ananthakrishnan, G., Bort, A., Seeley, R. J., Tschop, M. H., Dietrich, D. R., and Pfluger, P. T 2012. High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. Disease models & mechanisms, 5, 627-635
Stemmer, Kerstin; Perez-Tilve, Diego; Ananthakrishnan, Gayathri; Bort, Anja; Seeley, Randy J; Tschöp, Matthias H; Dietrich, Daniel R; Pfluger, Paul T 2012. High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. Disease models & mechanisms, 5 5, 627-35
Wiedmer, P., Chaudhary, N., Rath, M., Yi, C. X., Ananthakrishnan, G., Nogueiras, R., Wirth, E. K., Kirchner, H., Schweizer, U., Jonas, W., Veyrat-Durebex, C., Rohner-Jeanrenaud, F., Schurmann, A., Joost, H. G., Tschop, M. H., and Perez-Tilve, D. 2012. The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. Physiology & behavior , 105, 791-799
Yi, C. X., Heppner, K. M., Kirchner, H., Tong, J., Bielohuby, M., Gaylinn, B. D., Muller, T. D., Bartley, E., Davis, H. W., Zhao, Y., Joseph, A., Kruthaupt, T., Ottaway, N., Kabra, D., Habegger, K. M., Benoit, S. C., Bidlingmaier, M., Thorner, M. O., Perez-Tilve, D., Tschop, M. H., and Pfluger, P. T. 2012. The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. PLoS ONE, 7 , 321
Habegger, Kirk M; Grant, Erin; Pfluger, Paul Thomas; Perez-Tilve, Diego; Daugherty, Alan; Bruemmer, Dennis; Tschöp, Matthias H; Hofmann, Susanna M 2011. Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice. Frontiers in endocrinology, 2 , 67
Lockie, Sarah Haas; Czyzyk, Traci A; Chaudhary, Nilika; Perez-Tilve, Diego; Woods, Stephen C; Oldfield, Brian J; Statnick, Michael A; Tschöp, Matthias H 2011. CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice. Endocrinology, 152 10, 3661-7
Patterson, James T; Ottaway, Nickki; Gelfanov, Vasily M; Smiley, David L; Perez-Tilve, Diego; Pfluger, Paul T; Tschöp, Matthias H; Dimarchi, Richard D 2011. A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1. ACS chemical biology, 6 2, 135-45
Perez-Tilve, Diego; Davidson, W Sean; Tschöp, Matthias; Hofmann, Susanna M 2011. CNS regulation of plasma cholesterol. Annals of medicine, ,
Perez-Tilve, Diego; Habbeger, Kirk M; Tschöp, Matthias H; Hofmann, Susanna M 2011. Neural regulation of cholesterol metabolism. Current opinion in lipidology, 22 4, 283-7
Perez-Tilve, Diego; Heppner, Kristy; Kirchner, Henriette; Lockie, Sarah H; Woods, Stephen C; Smiley, David L; Tschöp, Matthias; Pfluger, Paul 2011. Ghrelin-induced adiposity is independent of orexigenic effects. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,
Pfluger, Paul T; Castañeda, Tamara R; Heppner, Kristy M; Strassburg, Sabine; Kruthaupt, Traci; Chaudhary, Nilika; Halem, Heather; Culler, Michael D; Datta, Rakesh; Burget, Lukas; Tschöp, M H; Nogueiras, Ruben; Perez-Tilve, Diego 2011. Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. Physiology & behavior, ,
Gil-Lozano, Manuel; Pérez-Tilve, Diego; Alvarez-Crespo, Mayte; Martís, Aurelio; Fernandez, Ana M; Catalina, Pablo A F; Gonzalez-Matias, Lucas C; Mallo, Federico 2010. GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans. Endocrinology, 151 6, 2629-40
Heppner, Kristy M; Habegger, Kirk M; Day, Jonathan; Pfluger, Paul T; Perez-Tilve, Diego; Ward, Brian; Gelfanov, Vasily; Woods, Steve C; DiMarchi, Richard; Tschöp, Matthias 2010. Glucagon regulation of energy metabolism. Physiology & behavior, 100 5, 545-8
Horvath, Tamas L; Sarman, Beatrix; García-Cáceres, Cristina; Enriori, Pablo J; Sotonyi, Peter; Shanabrough, Marya; Borok, Erzsebet; Argente, Jesus; Chowen, Julie A; Perez-Tilve, Diego; Pfluger, Paul T; Brönneke, Hella S; Levin, Barry E; Diano, Sabrina; Cowley, Michael A; Tschöp, Matthias H 2010. Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proceedings of the National Academy of Sciences of the United States of America, 107 33, 14875-80
Lee, Sang Jun; Kim, Ji Young; Nogueiras, Ruben; Linares, Juan F; Perez-Tilve, Diego; Jung, Dae Young; Ko, Hwi Jin; Hofmann, Susanna M; Drew, Angela; Leitges, Michael; Kim, Jason K; Tschöp, Matthias H; Diaz-Meco, Maria T; Moscat, Jorge 2010. PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell metabolism, 12 1, 65-77
Müller, Timo D; Perez-Tilve, Diego; Tong, Jenny; Pfluger, Paul T; Tschöp, Matthias H 2010. Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia. Journal of cachexia, sarcopenia and muscle, 1 2, 159-167
Pérez-Tilve, Diego; González-Matías, Lucas; Aulinger, Benedikt A; Alvarez-Crespo, Mayte; Gil-Lozano, Manuel; Alvarez, Elias; Andrade-Olivie, Amalia M; Tschöp, Matthias H; D'Alessio, David A; Mallo, Federico 2010. Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system. American journal of physiology. Endocrinology and metabolism, 298 5, E1088-96
Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H 2010. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nature neuroscience, 13 7, 877-82
Stefater, Margaret A; Pérez-Tilve, Diego; Chambers, Adam P; Wilson-Pérez, Hilary E; Sandoval, Darleen A; Berger, José; Toure, Mouhamadoul; Tschöp, Matthias; Woods, Stephen C; Seeley, Randy J 2010. Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology, 138 7, 2426-36, 2436.e1-3
Strassburg, Sabine; Pfluger, Paul T; Chaudhary, Nilika; Tso, Patrick; Tschöp, Matthias H; Anker, Stefan D; Nogueiras, Ruben; Perez-Tilve, Diego 2010. Action profile of the antiobesity drug candidate oleoyl-estrone in rats. Obesity (Silver Spring, Md.), 18 12, 2260-7
Sutton, Gregory M; Begriche, Karima; Kumar, K Ganesh; Gimble, Jeffrey M; Perez-Tilve, Diego; Nogueiras, Ruben; McMillan, Ryan P; Hulver, Matthew W; Tschöp, Matthias H; Butler, Andrew A 2010. Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24 3, 862-72
Tschöp, Johannes; Nogueiras, Ruben; Haas-Lockie, Sarah; Kasten, Kevin R; Castañeda, Tamara R; Huber, Nadine; Guanciale, Kelsey; Perez-Tilve, Diego; Habegger, Kirk; Ottaway, Nickki; Woods, Stephen C; Oldfield, Brian; Clarke, Iain; Chua, Streamson; Farooqi, I Sadaf; O'Rahilly, Stephen; Caldwell, Charles C; Tschöp, Matthias H 2010. CNS leptin action modulates immune response and survival in sepsis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 17, 6036-47
Day, Jonathan W; Ottaway, Nickki; Patterson, James T; Gelfanov, Vasily; Smiley, David; Gidda, Jas; Findeisen, Hannes; Bruemmer, Dennis; Drucker, Daniel J; Chaudhary, Nilika; Holland, Jenna; Hembree, Jazzminn; Abplanalp, William; Grant, Erin; Ruehl, Jennifer; Wilson, Hilary; Kirchner, Henriette; Lockie, Sarah Haas; Hofmann, Susanna; Woods, Stephen C; Nogueiras, Ruben; Pfluger, Paul T; Perez-Tilve, Diego; DiMarchi, Richard; Tschöp, Matthias H 2009. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nature chemical biology, 5 10, 749-57
Nogueiras, Ruben; Pérez-Tilve, Diego; Veyrat-Durebex, Christelle; Morgan, Donald A; Varela, Luis; Haynes, William G; Patterson, James T; Disse, Emmanuel; Pfluger, Paul T; López, Miguel; Woods, Stephen C; DiMarchi, Richard; Diéguez, Carlos; Rahmouni, Kamal; Rohner-Jeanrenaud, Françoise; Tschöp, Matthias H 2009. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29 18, 5916-25
Hofmann, Susanna M; Perez-Tilve, Diego; Greer, Todd M; Coburn, Beth A; Grant, Erin; Basford, Joshua E; Tschöp, Matthias H; Hui, David Y 2008. Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes, 57 1, 5-12
López, Miguel; Lage, Ricardo; Saha, Asish K; Pérez-Tilve, Diego; Vázquez, María J; Varela, Luis; Sangiao-Alvarellos, Susana; Tovar, Sulay; Raghay, Kawtar; Rodríguez-Cuenca, Sergio; Deoliveira, Rosangela M; Castañeda, Tamara; Datta, Rakesh; Dong, Jesse Z; Culler, Michael; Sleeman, Mark W; Alvarez, Clara V; Gallego, Rosalía; Lelliott, Christopher J; Carling, David; Tschöp, Matthias H; Diéguez, Carlos; Vidal-Puig, Antonio 2008. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell metabolism, 7 5, 389-99
Nogueiras, Ruben; López, Miguel; Lage, Ricardo; Perez-Tilve, Diego; Pfluger, Paul; Mendieta-Zerón, Hugo; Sakkou, Maria; Wiedmer, Petra; Benoit, Stephen C; Datta, Rakesh; Dong, Jesse Z; Culler, Michael; Sleeman, Mark; Vidal-Puig, Antonio; Horvath, Tamas; Treier, Mathias; Diéguez, Carlos; Tschöp, Matthias H 2008. Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology, 149 6, 3009-15
Perez-Tilve, Diego; D'Alessio, David A; Tschöp, Matthias H 2008. A sweet spot for the bariatric surgeon. Cell metabolism, 8 3, 177-9
Pfluger, Paul T; Kirchner, Henriette; Günnel, Susanne; Schrott, Brigitte; Perez-Tilve, Diego; Fu, Sheng; Benoit, Stephen C; Horvath, Tamas; Joost, Hans-Georg; Wortley, Katherine E; Sleeman, Mark W; Tschöp, Matthias H 2008. Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. American journal of physiology. Gastrointestinal and liver physiology, 294 3, G610-8
Strassburg, Sabine; Anker, Stefan D; Castaneda, Tamara R; Burget, Lukas; Perez-Tilve, Diego; Pfluger, Paul T; Nogueiras, Ruben; Halem, Heather; Dong, Jesse Z; Culler, Michael D; Datta, Rakesh; Tschöp, Matthias H 2008. Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. American journal of physiology. Endocrinology and metabolism, 295 1, E78-84
Sutton, Gregory M; Perez-Tilve, Diego; Nogueiras, Ruben; Fang, Jidong; Kim, Jason K; Cone, Roger D; Gimble, Jeffrey M; Tschöp, Matthias H; Butler, Andrew A 2008. The melanocortin-3 receptor is required for entrainment to meal intake. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28 48, 12946-55
Tizzano, Joseph P; Stribling, D Sloan; Perez-Tilve, Diego; Strack, Alison; Frassetto, Andrea; Chen, Richard Z; Fong, Tung M; Shearman, Lauren; Krieter, Philip A; Tschöp, Matthias H; Skolnick, Phil; Basile, Anthony S 2008. The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. The Journal of pharmacology and experimental therapeutics, 324 3, 1111-26
Hofmann, Susanna M; Zhou, Li; Perez-Tilve, Diego; Greer, Todd; Grant, Erin; Wancata, Lauren; Thomas, Andrew; Pfluger, Paul T; Basford, Joshua E; Gilham, Dean; Herz, Joachim; Tschöp, Matthias H; Hui, David Y 2007. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. The Journal of clinical investigation, 117 11, 3271-82
Nogueiras, Rubén; Pfluger, Paul; Tovar, Sulay; Arnold, Myrtha; Mitchell, Sharon; Morris, Amanda; Perez-Tilve, Diego; Vázquez, Maria J; Wiedmer, Petra; Castañeda, Tamara R; DiMarchi, Richard; Tschöp, Matthias; Schurmann, Annette; Joost, Hans-Georg; Williams, Lynda M; Langhans, Wolfgang; Diéguez, Carlos 2007. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology, 148 1, 21-6
Nogueiras, Ruben; Wiedmer, Petra; Perez-Tilve, Diego; Veyrat-Durebex, Christelle; Keogh, Julia M; Sutton, Gregory M; Pfluger, Paul T; Castaneda, Tamara R; Neschen, Susanne; Hofmann, Susanna M; Howles, Philip N; Morgan, Donald A; Benoit, Stephen C; Szanto, Ildiko; Schrott, Brigitte; Schürmann, Annette; Joost, Hans-Georg; Hammond, Craig; Hui, David Y; Woods, Stephen C; Rahmouni, Kamal; Butler, Andrew A; Farooqi, I Sadaf; O'Rahilly, Stephen; Rohner-Jeanrenaud, Françoise; Tschöp, Matthias H 2007. The central melanocortin system directly controls peripheral lipid metabolism. The Journal of clinical investigation, 117 11, 3475-88
Nomiyama, Takashi; Perez-Tilve, Diego; Ogawa, Daisuke; Gizard, Florence; Zhao, Yue; Heywood, Elizabeth B; Jones, Karrie L; Kawamori, Ryuzo; Cassis, Lisa A; Tschöp, Matthias H; Bruemmer, Dennis 2007. Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. The Journal of clinical investigation, 117 10, 2877-88
Pérez-Tilve, Diego; González-Matías, Lucas; Alvarez-Crespo, Mayte; Leiras, Roberto; Tovar, Sulay; Diéguez, Carlos; Mallo, Federico 2007. Exendin-4 potently decreases ghrelin levels in fasting rats. Diabetes, 56 1, 143-51
Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Alvarez-Crespo, Mayte; Mallo, Federico 2007. Prolactin-releasing Peptide (PrRP) increases prolactin responses to TRH in vitro and in vivo. Endocrine, 31 2, 119-24
Perez-Tilve, Diego; Nogueiras, Ruben; Mallo, Federico; Benoit, Stephen C; Tschoep, Matthias 2006. Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism. Endocrine, 29 1, 61-71
Perez-Tilve, Diego; Stern, Javier E; Tschöp, Matthias 2006. The brain and the metabolic syndrome: not a wireless connection. Endocrinology, 147 3, 1136-9
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