Education/Credentials2004 -2009 Postdoctoral Fellowship : Obesity Research Center and Genome Research Institute, University of Cincinnati (Psychiatry)Doctoral Degree: University of Vigo (Biological Sciences): Faculty of Sciences, University of Vigo (Biology) Contact Information Office 513-558-2001 Email pereztdo@ucmail.uc.edu Peer Reviewed Publications El, Kimberley; Douros, Jonathan D; Willard, Francis S; Novikoff, Aaron; Sargsyan, Ashot; Perez-Tilve, Diego; Wainscott, David B; Yang, Bin; Chen, Alex; Wothe, Donald; Coupland, Callum; Tschöp, Mattias H; Finan, Brian; D'Alessio, David A; Sloop, Kyle W; Müller, Timo D; Campbell, Jonathan E 2023. The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets. Nature metabolism, 5 6, 945-954Knerr, Patrick J; Mowery, Stephanie A; Douros, Jonathan D; Premdjee, Bhavesh; Hjøllund, Karina Rahr; He, Yantao; Kruse Hansen, Ann Maria; Olsen, Anette K; Perez-Tilve, Diego; DiMarchi, Richard D; Finan, Brian 2022. Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice. Molecular metabolism, 63 , 101533Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego 2022. Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons. Neuroendocrinology, 112 3, 287-297Quarta, Carmelo; Stemmer, Kerstin; Novikoff, Aaron; Yang, Bin; Klingelhuber, Felix; Harger, Alex; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Baugé, Eric; Campbell, Jonathan E; Capozzi, Megan; Clemmensen, Christoffer; Collden, Gustav; Cota, Perla; Douros, Jon; Drucker, Daniel J; DuBois, Barent; Feuchtinger, Annette; Garcia-Caceres, Cristina; Grandl, Gerald; Hennuyer, Nathalie; Herzig, Stephan; Hofmann, Susanna M; Knerr, Patrick J; Kulaj, Konxhe; Lalloyer, Fanny; Lickert, Heiko; Liskiewicz, Arek; Liskiewicz, Daniela; Maity, Gandhari; Perez-Tilve, Diego; Prakash, Sneha; Sanchez-Garrido, Miguel A; Zhang, Qian; Staels, Bart; Krahmer, Natalie; DiMarchi, Richard D; Tschöp, Matthias H; Finan, Brian; Müller, Timo D 2022. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature metabolism, 4 8, 1071-1083Yang, Bin; Gelfanov, Vasily M; El, Kimberley; Chen, Alex; Rohlfs, Rebecca; DuBois, Barent; Kruse Hansen, Ann Maria; Perez-Tilve, Diego; Knerr, Patrick J; D'Alessio, David; Campbell, Jonathan E; Douros, Jonathan D; Finan, Brian 2022. Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems. Molecular metabolism, 66 , 101638Yang, Bin; Gelfanov, Vasily M; Perez-Tilve, Diego; DuBois, Barent; Rohlfs, Rebecca; Levy, Jay; Douros, Jonathan D; Finan, Brian; Mayer, John P; DiMarchi, Richard D 2021. Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists. Journal of medicinal chemistry, 64 8, 4697-4708Zhang, Qian; Delessa, Challa Tenagne; Augustin, Robert; Bakhti, Mostafa; Colldén, Gustav; Drucker, Daniel J; Feuchtinger, Annette; Caceres, Cristina Garcia; Grandl, Gerald; Harger, Alexandra; Herzig, Stephan; Hofmann, Susanna; Holleman, Cassie Lynn; Jastroch, Martin; Keipert, Susanne; Kleinert, Maximilian; Knerr, Patrick J; Kulaj, Konxhe; Legutko, Beata; Lickert, Heiko; Liu, Xue; Luippold, Gerd; Lutter, Dominik; Malogajski, Emilija; Medina, Marta Tarquis; Mowery, Stephanie A; Blutke, Andreas; Perez-Tilve, Diego; Salinno, Ciro; Sehrer, Laura; DiMarchi, Richard D; Tschöp, Matthias H; Stemmer, Kerstin; Finan, Brian; Wolfrum, Christian; Müller, Timo D 2021. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell metabolism, 33 4, 833-844.e5Zizzari, Philippe; He, Rongjun; Falk, Sarah; Bellocchio, Luigi; Allard, Camille; Clark, Samantha; Lesté-Lasserre, Thierry; Marsicano, Giovanni; Clemmensen, Christoffer; Perez-Tilve, Diego; Finan, Brian; Cota, Daniela; Quarta, Carmelo 2021. CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity. Diabetes, 70 2, 415-422Kabotso, Daniel E K; Smiley, David; Mayer, John P; Gelfanov, Vasily M; Perez-Tilve, Diego; DiMarchi, Richard D; Pohl, Nicola L B; Liu, Fa 2020. Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence. Journal of medicinal chemistry, 63 11, 6134-6143Knerr, Patrick J; Mowery, Stephanie A; Finan, Brian; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D 2020. Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates. Peptides, 125 , 170225Pan, Jia; Parlee, Sebastian D; Brunel, Florence M; Li, Pengyun; Lu, Wei; Perez-Tilve, Diego; Liu, Fa; Finan, Brian; Kharitonenkov, Alexei; DiMarchi, Richard D 2020. Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21. ACS pharmacology & translational science, 3 5, 978-986Perez-Tilve, Diego 2020. Glucagon Peptide Family and Adipose Tissue: Not that Intimate, just Acquaintances. Endocrinology, 161 2, Sorrell, Joyce; Yates, Emily; Rivir, Marita; Woods, Stephen C; Hogenesch, John B; Perez-Tilve, Diego 2020. The central melanocortin system mediates the benefits of time-restricted feeding on energy balance. Physiology & behavior, 227 , 113132Brunel, Florence M; Mayer, John P; Gelfanov, Vasily M; Zaykov, Alexander N; Finan, Brian; Perez-Tilve, Diego; DiMarchi, Richard D 2019. A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity. ACS chemical biology, 14 8, 1829-1835Holland, Jenna; Sorrell, Joyce; Yates, Emily; Smith, Kathleen; Arbabi, Shahriar; Arnold, Myrtha; Rivir, Marita; Morano, Rachel; Chen, Jenny; Zhang, Xiang; Dimarchi, Richard; Woods, Stephen C; Sanchez-Gurmaches, Joan; Wohleb, Eric; Perez-Tilve, Diego 2019. A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Cell reports, 27 8, 2399-2410.e6Mroz, Piotr A; Finan, Brian; Gelfanov, Vasily; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D; Perez-Tilve, Diego 2019. Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism. Molecular metabolism, 20 , 51-62Müller, T D; Finan, B; Bloom, S R; D'Alessio, D; Drucker, D J; Flatt, P R; Fritsche, A; Gribble, F; Grill, H J; Habener, J F; Holst, J J; Langhans, W; Meier, J J; Nauck, M A; Perez-Tilve, D; Pocai, A; Reimann, F; Sandoval, D A; Schwartz, T W; Seeley, R J; Stemmer, K; Tang-Christensen, M; Woods, S C; DiMarchi, R D; Tschöp, M H 2019. Glucagon-like peptide 1 (GLP-1). Molecular metabolism, 30 , 72-130Perez-Tilve, Diego 2019. 'Et Tu, Leptin?'. Trends in endocrinology and metabolism: TEM, 30 4, 232-233Zaykov, Alexander N; Gelfanov, Vasily M; Perez-Tilve, Diego; Finan, Brian; DiMarchi, Richard D 2019. Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice. Peptides, 120 , 170116Agrawal, Archita; Parlee, Sebastian; Perez-Tilve, Diego; Li, Pengyun; Pan, Jia; Mroz, Piotr A; Kruse Hansen, Ann Maria; Andersen, Birgitte; Finan, Brian; Kharitonenkov, Alexei; DiMarchi, Richard D 2018. Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. Molecular metabolism, , Kim, Teayoun; Holleman, Cassie L; Nason, Shelly; Arble, Deanna M; Ottaway, Nickki; Chabenne, Joseph; Loyd, Christine; Kim, Jeong-A; Sandoval, Darleen; Drucker, Daniel J; DiMarchi, Richard; Perez-Tilve, Diego; Habegger, Kirk M 2018. Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents. Diabetes, 67 11, 2157-2166Kim, Teayoun; Nason, Shelly; Holleman, Cassie; Pepin, Mark; Wilson, Landon; Berryhill, Taylor F; Wende, Adam R; Steele, Chad; Young, Martin E; Barnes, Stephen; Drucker, Daniel J; Finan, Brian; DiMarchi, Richard; Perez-Tilve, Diego; Tschöp, Matthias; Habegger, Kirk M 2018. Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes, 67 9, 1773-1782Mahbod, Parinaz; Smith, Eric P; Fitzgerald, Maureen E; Morano, Rachel L; Packard, Benjamin A; Ghosal, Sriparna; Scheimann, Jessie R; Perez-Tilve, Diego; Herman, James P; Tong, Jenny 2018. Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice. Endocrinology, 159 1, 388-399Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620Rivero-Gutierrez, Belen; Haller, April; Holland, Jenna; Yates, Emily; Khrisna, Radha; Habegger, Kirk; Dimarchi, Richard; D'Alessio, David; Perez-Tilve, Diego 2018. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Molecular metabolism, 17 , 28-38Ryan, Karen K; Packard, Amy E B; Larson, Karlton R; Stout, Jayna; Fourman, Sarah M; Thompson, Abigail M K; Ludwick, Kristen; Habegger, Kirk M; Stemmer, Kerstin; Itoh, Nobuyuki; Perez-Tilve, Diego; Tschöp, Matthias H; Seeley, Randy J; Ulrich-Lai, Yvonne M 2018. Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21. Endocrinology, 159 1, 400-413Knerr, Patrick J; Finan, Brian; Gelfanov, Vasily; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D 2017. Optimization of peptide-based polyagonists for treatment of diabetes and obesity. Bioorganic & medicinal chemistry, , Perez-Tilve, Diego 2017. Novel Hypothalamic Mechanisms in the Pathophysiological Control of Body Weight and Metabolism. Endocrinology, 158 5, 1085-1094Quarta, Carmelo; Clemmensen, Christoffer; Zhu, Zhimeng; Yang, Bin; Joseph, Sini S; Lutter, Dominik; Yi, Chun-Xia; Graf, Elisabeth; García-Cáceres, Cristina; Legutko, Beata; Fischer, Katrin; Brommage, Robert; Zizzari, Philippe; Franklin, Bernardo S; Krueger, Martin; Koch, Marco; Vettorazzi, Sabine; Li, Pengyun; Hofmann, Susanna M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Lickert, Heiko; Strom, Tim M; Gailus-Durner, Valerie; Bechmann, Ingo; Perez-Tilve, Diego; Tuckermann, Jan; Hrab? de Angelis, Martin; Sandoval, Darleen; Cota, Daniela; Latz, Eicke; Seeley, Randy J; Müller, Timo D; DiMarchi, Richard D; Finan, Brian; Tschöp, Matthias H 2017. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell metabolism, 26 4, 620-632.e6Finan, Brian; Clemmensen, Christoffer; Zhu, Zhimeng; Stemmer, Kerstin; Gauthier, Karine; Müller, Luisa; De Angelis, Meri; Moreth, Kristin; Neff, Frauke; Perez-Tilve, Diego; Fischer, Katrin; Lutter, Dominik; Sánchez-Garrido, Miguel A; Liu, Peng; Tuckermann, Jan; Malehmir, Mohsen; Healy, Marc E; Weber, Achim; Heikenwalder, Mathias; Jastroch, Martin; Kleinert, Maximilian; Jall, Sigrid; Brandt, Sara; Flamant, Frédéric; Schramm, Karl-Werner; Biebermann, Heike; Döring, Yvonne; Weber, Christian; Habegger, Kirk M; Keuper, Michaela; Gelfanov, Vasily; Liu, Fa; Köhrle, Josef; Rozman, Jan; Fuchs, Helmut; Gailus-Durner, Valerie; Hrab? de Angelis, Martin; Hofmann, Susanna M; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard; Müller, Timo D 2016. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell, 167 3, 843-857.e14Finan, Brian; Müller, Timo D; Clemmensen, Christoffer; Perez-Tilve, Diego; DiMarchi, Richard D; Tschöp, Matthias H 2016. Reappraisal of GIP Pharmacology for Metabolic Diseases. Trends in molecular medicine, 22 5, 359-76Kabra, Dhiraj G; Pfuhlmann, Katrin; García-Cáceres, Cristina; Schriever, Sonja C; Casquero García, Veronica; Kebede, Adam Fiseha; Fuente-Martin, Esther; Trivedi, Chitrang; Heppner, Kristy; Uhlenhaut, N Henriette; Legutko, Beata; Kabra, Uma D; Gao, Yuanqing; Yi, Chun-Xia; Quarta, Carmelo; Clemmensen, Christoffer; Finan, Brian; Müller, Timo D; Meyer, Carola W; Paez-Pereda, Marcelo; Stemmer, Kerstin; Woods, Stephen C; Perez-Tilve, Diego; Schneider, Robert; Olson, Eric N; Tschöp, Matthias H; Pfluger, Paul T 2016. Hypothalamic leptin action is mediated by histone deacetylase 5. Nature communications, 7 , 10782Loyd, Christine; Magrisso, I Jack; Haas, Michael; Balusu, Sowmya; Krishna, Radha; Itoh, Nobuyuki; Sandoval, Darleen A; Perez-Tilve, Diego; Obici, Silvana; Habegger, Kirk M 2016. Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding. Journal of applied physiology (Bethesda, Md. : 1985), 121 3, 687-98Mroz, Piotr A; Perez-Tilve, Diego; Liu, Fa; Gelfanov, Vasily; DiMarchi, Richard D; Mayer, John P 2016. Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization. Journal of medicinal chemistry, 59 17, 8061-7Mroz, Piotr A; Perez-Tilve, Diego; Liu, Fa; Mayer, John P; DiMarchi, Richard D 2016. Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon. ACS chemical biology, 11 12, 3412-3420Raab, Susanne; Wang, Haiyan; Uhles, Sabine; Cole, Nadine; Alvarez-Sanchez, Ruben; Künnecke, Basil; Ullmer, Christoph; Matile, Hugues; Bedoucha, Marc; Norcross, Roger D; Ottaway-Parker, Nickki; Perez-Tilve, Diego; Conde Knape, Karin; Tschöp, Matthias H; Hoener, Marius C; Sewing, Sabine 2016. Incretin-like effects of small molecule trace amine-associated receptor 1 agonists. Molecular metabolism, 5 1, 47-56Sánchez-Garrido, Miguel Angel; Habegger, Kirk M; Clemmensen, Christoffer; Holleman, Cassie; Müller, Timo D; Perez-Tilve, Diego; Li, Pengyun; Agrawal, Archita S; Finan, Brian; Drucker, Daniel J; Tschöp, Matthias H; DiMarchi, Richard D; Kharitonenkov, Alexei 2016. Fibroblast activation protein (FAP) as a novel metabolic target. Molecular metabolism, 5 10, 1015-24Tschöp, Matthias H; Finan, Brian; Clemmensen, Christoffer; Gelfanov, Vasily; Perez-Tilve, Diego; Müller, Timo D; DiMarchi, Richard D 2016. Unimolecular Polypharmacy for Treatment of Diabetes and Obesity. Cell metabolism, 24 1, 51-62Arble, Deanna M; Holland, Jenna; Ottaway, Nickki; Sorrell, Joyce; Pressler, Joshua W; Morano, Rachel; Woods, Stephen C; Seeley, Randy J; Herman, James P; Sandoval, Darleen A; Perez-Tilve, Diego 2015. The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology, 156 5, 1685-91Finan, Brian; Yang, Bin; Ottaway, Nickki; Smiley, David L; Ma, Tao; Clemmensen, Christoffer; Chabenne, Joe; Zhang, Lianshan; Habegger, Kirk M; Fischer, Katrin; Campbell, Jonathan E; Sandoval, Darleen; Seeley, Randy J; Bleicher, Konrad; Uhles, Sabine; Riboulet, William; Funk, Jürgen; Hertel, Cornelia; Belli, Sara; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; Drucker, Daniel J; Gelfanov, Vasily; Pfluger, Paul T; Müller, Timo D; Perez-Tilve, Diego; DiMarchi, Richard D; Tschöp, Matthias H 2015. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nature medicine, 21 1, 27-36Heppner, Kristy M; Marks, Sarah; Holland, Jenna; Ottaway, Nickki; Smiley, David; Dimarchi, Richard; Perez-Tilve, Diego 2015. Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice. Diabetologia, 58 9, 2124-32Heppner, Kristy M; Perez-Tilve, Diego 2015. GLP-1 based therapeutics: simultaneously combating T2DM and obesity. Frontiers in neuroscience, 9 , 92Müller, T D; Nogueiras, R; Andermann, M L; Andrews, Z B; Anker, S D; Argente, J; Batterham, R L; Benoit, S C; Bowers, C Y; Broglio, F; Casanueva, F F; D'Alessio, D; Depoortere, I; Geliebter, A; Ghigo, E; Cole, P A; Cowley, M; Cummings, D E; Dagher, A; Diano, S; Dickson, S L; Diéguez, C; Granata, R; Grill, H J; Grove, K; Habegger, K M; Heppner, K; Heiman, M L; Holsen, L; Holst, B; Inui, A; Jansson, J O; Kirchner, H; Korbonits, M; Laferrère, B; LeRoux, C W; Lopez, M; Morin, S; Nakazato, M; Nass, R; Perez-Tilve, D; Pfluger, P T; Schwartz, T W; Seeley, R J; Sleeman, M; Sun, Y; Sussel, L; Tong, J; Thorner, M O; van der Lely, A J; van der Ploeg, L H T; Zigman, J M; Kojima, M; Kangawa, K; Smith, R G; Horvath, T; Tschöp, M H 2015. Ghrelin. Molecular metabolism, 4 6, 437-60Ottaway, Nickki; Mahbod, Parinaz; Rivero, Belen; Norman, Lee Ann; Gertler, Arieh; D'Alessio, David A; Perez-Tilve, Diego 2015. Diet-induced obese mice retain endogenous leptin action. Cell metabolism, 21 6, 877-82Pfluger, Paul T; Kabra, Dhiraj G; Aichler, Michaela; Schriever, Sonja C; Pfuhlmann, Katrin; García, Verónica Casquero; Lehti, Maarit; Weber, Jon; Kutschke, Maria; Rozman, Jan; Elrod, John W; Hevener, Andrea L; Feuchtinger, Annette; Hrab? de Angelis, Martin; Walch, Axel; Rollmann, Stephanie M; Aronow, Bruce J; Müller, Timo D; Perez-Tilve, Diego; Jastroch, Martin; De Luca, Maria; Molkentin, Jeffery D; Tschöp, Matthias H 2015. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell metabolism, 22 5, 838-50Trivedi, Chitrang; Shan, Xiaoye; Tung, Yi-Chun Loraine; Kabra, Dhiraj; Holland, Jenna; Amburgy, Sarah; Heppner, Kristy; Kirchner, Henriette; Yeo, Giles S H; Perez-Tilve, Diego 2015. Tachykinin-1 in the central nervous system regulates adiposity in rodents. Endocrinology, 156 5, 1714-23Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., Garcia-Caceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschop, M. H., and Yi, C. X. 2014. Hormones and diet, but not body weight, control hypothalamic microglial activity Glia , 62, 17-25Gao, Yuanqing; Ottaway, Nickki; Schriever, Sonja C; Legutko, Beata; García-Cáceres, Cristina; de la Fuente, Esther; Mergen, Clarita; Bour, Susanne; Thaler, Joshua P; Seeley, Randy J; Filosa, Jessica; Stern, Javier E; Perez-Tilve, Diego; Schwartz, Michael W; Tschöp, Matthias H; Yi, Chun-Xia 2014. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia, 62 1, 17-25Habegger, K. M., Heppner, K. M., Amburgy, S. E., Ottaway, N., Holland, J., Raver, C., Bartley, E., Muller, T. D., Pfluger, P. T., Berger, J., Toure, M., Benoit, S. C., Dimarchi, R. D., Perez-Tilve, D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. 2014. GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats. Diabetes., 63, 505-13Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; Dimarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2014. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes, 63 2, 505-13Heppner, K. M., Piechowski, C. L., Muller, A.,D. A., and Perez-Tilve, D. Ottaway, N., Sisley, S., Smiley, D. L., Habegger, K. M., Pfluger, P. T., Dimarchi, R., Biebermann, H., Tschop, M. H., Sandoval, 2014. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes., 63, 122-131Heppner, Kristy M; Piechowski, Carolin L; Müller, Anne; Ottaway, Nickki; Sisley, Stephanie; Smiley, David L; Habegger, Kirk M; Pfluger, Paul T; Dimarchi, Richard; Biebermann, Heike; Tschöp, Matthias H; Sandoval, Darleen A; Perez-Tilve, Diego 2014. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes, 63 1, 122-31Smith, Eric P; An, Zhibo; Wagner, Constance; Lewis, Alfor G; Cohen, Eric B; Li, Bailing; Mahbod, Parinaz; Sandoval, Darleen; Perez-Tilve, Diego; Tamarina, Natalia; Philipson, Louis H; Stoffers, Doris A; Seeley, Randy J; D'Alessio, David A 2014. The role of ? cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. Cell metabolism, 19 6, 1050-7Finan, B., Ma, T., Ottaway, N., Muller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., Lockie, S. H., Smiley, D. L., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D. J., Pfluger, P. T., Perez-Tilve, D., Gidda, J., Vignati, L., Zhang, L., Hauptman, J. B., Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, E., Sebokova, E., Conde-Knape, K., Konkar, A., DiMarchi, R. D., and Tschop, M. H. 2013. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Science translational medicine, 5, 209-151Gadang, V., Kohli, R., Myronovych, A., Hui, D. Y., Perez-Tilve, D., and Jaeschke, A. 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism , 305, 549-556Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism, 305 4, E549-56Habegger, K. M., Al-Massadi, O., Heppner, K. M., Myronovych, A., Holland, J., Berger, J., Yi, C. X., Gao, Y., Lehti, M., Ottaway, N., Amburgy, S., Raver, C., Muller, T. D., Pfluger, P. T., Kohli, R., Perez-Tilve, D., Seeley, R. J., and Tschop, M. H. 2013. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut , , Habegger, K. M., Kirchner, H., Yi, C. X., Heppner, K. M., Sweeney, D., Ottaway, N., Holland, J., Amburgy, S., Raver, C., Krishna, R., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Obici, S., DiMarchi, R. D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. 2013. GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes., 62, 3261-3267Habegger, K. M., Stemmer, K., Cheng, C., Muller, T. D., Heppner, K. M., Ottaway, N., Holland, J., Hembree, J. L., Smiley, D., Gelfanov, V., Krishna, R., Arafat, A. M., Konkar,A., Belli, S., Kapps, M., Woods, S. C., Hofmann, S. M., D'Alessio, D., Pfluger, P. T., Perez-Tilve, D., Seeley, R. J., Konishi, M., Itoh, N., Kharitonenkov, A., Spranger, J., DiMarchi, R. D., and Tschop, M. H. 2013. Fibroblast growth factor 21 mediates specific glucagon actions Diabetes, 62, 1453-1463Habegger, Kirk M; Al-Massadi, Omar; Heppner, Kristy M; Myronovych, Andriy; Holland, Jenna; Berger, Jose; Yi, Chun-Xia; Gao, Yuanging; Lehti, Maarit; Ottaway, Nickki; Amburgy, Sarah; Raver, Christine; Müller, Timo D; Pfluger, Paul T; Kohli, Rohit; Perez-Tilve, Diego; Seeley, Randy J; Tschöp, Matthias H 2013. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut, , Habegger, Kirk M; Kirchner, Henriette; Yi, Chun-Xia; Heppner, Kristy M; Sweeney, Dan; Ottaway, Nickki; Holland, Jenna; Amburgy, Sarah; Raver, Christine; Krishna, Radhakrishna; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Obici, Silvana; DiMarchi, Richard D; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2013. 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The Journal of neuroscience : the official journal of the Society for Neuroscience, 28 48, 12946-55Tizzano, Joseph P; Stribling, D Sloan; Perez-Tilve, Diego; Strack, Alison; Frassetto, Andrea; Chen, Richard Z; Fong, Tung M; Shearman, Lauren; Krieter, Philip A; Tschöp, Matthias H; Skolnick, Phil; Basile, Anthony S 2008. The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. The Journal of pharmacology and experimental therapeutics, 324 3, 1111-26Hofmann, Susanna M; Zhou, Li; Perez-Tilve, Diego; Greer, Todd; Grant, Erin; Wancata, Lauren; Thomas, Andrew; Pfluger, Paul T; Basford, Joshua E; Gilham, Dean; Herz, Joachim; Tschöp, Matthias H; Hui, David Y 2007. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. The Journal of clinical investigation, 117 11, 3271-82Nogueiras, Rubén; Pfluger, Paul; Tovar, Sulay; Arnold, Myrtha; Mitchell, Sharon; Morris, Amanda; Perez-Tilve, Diego; Vázquez, Maria J; Wiedmer, Petra; Castañeda, Tamara R; DiMarchi, Richard; Tschöp, Matthias; Schurmann, Annette; Joost, Hans-Georg; Williams, Lynda M; Langhans, Wolfgang; Diéguez, Carlos 2007. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology, 148 1, 21-6Nogueiras, Ruben; Wiedmer, Petra; Perez-Tilve, Diego; Veyrat-Durebex, Christelle; Keogh, Julia M; Sutton, Gregory M; Pfluger, Paul T; Castaneda, Tamara R; Neschen, Susanne; Hofmann, Susanna M; Howles, Philip N; Morgan, Donald A; Benoit, Stephen C; Szanto, Ildiko; Schrott, Brigitte; Schürmann, Annette; Joost, Hans-Georg; Hammond, Craig; Hui, David Y; Woods, Stephen C; Rahmouni, Kamal; Butler, Andrew A; Farooqi, I Sadaf; O'Rahilly, Stephen; Rohner-Jeanrenaud, Françoise; Tschöp, Matthias H 2007. The central melanocortin system directly controls peripheral lipid metabolism. The Journal of clinical investigation, 117 11, 3475-88Nomiyama, Takashi; Perez-Tilve, Diego; Ogawa, Daisuke; Gizard, Florence; Zhao, Yue; Heywood, Elizabeth B; Jones, Karrie L; Kawamori, Ryuzo; Cassis, Lisa A; Tschöp, Matthias H; Bruemmer, Dennis 2007. Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. The Journal of clinical investigation, 117 10, 2877-88Pérez-Tilve, Diego; González-Matías, Lucas; Alvarez-Crespo, Mayte; Leiras, Roberto; Tovar, Sulay; Diéguez, Carlos; Mallo, Federico 2007. Exendin-4 potently decreases ghrelin levels in fasting rats. Diabetes, 56 1, 143-51Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Alvarez-Crespo, Mayte; Mallo, Federico 2007. Prolactin-releasing Peptide (PrRP) increases prolactin responses to TRH in vitro and in vivo. Endocrine, 31 2, 119-24Perez-Tilve, Diego; Nogueiras, Ruben; Mallo, Federico; Benoit, Stephen C; Tschoep, Matthias 2006. Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism. Endocrine, 29 1, 61-71Perez-Tilve, Diego; Stern, Javier E; Tschöp, Matthias 2006. The brain and the metabolic syndrome: not a wireless connection. Endocrinology, 147 3, 1136-9Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Mallo, Federico 2006. Fibroblast growth factor-2 and epidermal growth factor modulate prolactin responses to TRH and dopamine in primary cultures. Endocrine, 29 2, 317-24Theander-Carrillo, Claudia; Wiedmer, Petra; Cettour-Rose, Philippe; Nogueiras, Ruben; Perez-Tilve, Diego; Pfluger, Paul; Castaneda, Tamara R; Muzzin, Patrick; Schürmann, Annette; Szanto, Ildiko; Tschöp, Matthias H; Rohner-Jeanrenaud, Françoise 2006. Ghrelin action in the brain controls adipocyte metabolism. The Journal of clinical investigation, 116 7, 1983-93Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Mallo, Federico 2004. Heparin increases prolactin and modifies the effects of fgf-2 upon prolactin accumulation in pituitary primary cultures. Endocrine, 24 2, 131-6Diz Chaves, Yolanda; Spuch Calvar, Carlos; Pérez Tilve, Diégo; Mallo Ferrer, Federico 2003. GH responses to GHRH and GHRP-6 in Streptozotocin (STZ)-diabetic rats. Life sciences, 73 26, 3375-85
Peer Reviewed Publications El, Kimberley; Douros, Jonathan D; Willard, Francis S; Novikoff, Aaron; Sargsyan, Ashot; Perez-Tilve, Diego; Wainscott, David B; Yang, Bin; Chen, Alex; Wothe, Donald; Coupland, Callum; Tschöp, Mattias H; Finan, Brian; D'Alessio, David A; Sloop, Kyle W; Müller, Timo D; Campbell, Jonathan E 2023. The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets. Nature metabolism, 5 6, 945-954Knerr, Patrick J; Mowery, Stephanie A; Douros, Jonathan D; Premdjee, Bhavesh; Hjøllund, Karina Rahr; He, Yantao; Kruse Hansen, Ann Maria; Olsen, Anette K; Perez-Tilve, Diego; DiMarchi, Richard D; Finan, Brian 2022. Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice. Molecular metabolism, 63 , 101533Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego 2022. Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons. Neuroendocrinology, 112 3, 287-297Quarta, Carmelo; Stemmer, Kerstin; Novikoff, Aaron; Yang, Bin; Klingelhuber, Felix; Harger, Alex; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Baugé, Eric; Campbell, Jonathan E; Capozzi, Megan; Clemmensen, Christoffer; Collden, Gustav; Cota, Perla; Douros, Jon; Drucker, Daniel J; DuBois, Barent; Feuchtinger, Annette; Garcia-Caceres, Cristina; Grandl, Gerald; Hennuyer, Nathalie; Herzig, Stephan; Hofmann, Susanna M; Knerr, Patrick J; Kulaj, Konxhe; Lalloyer, Fanny; Lickert, Heiko; Liskiewicz, Arek; Liskiewicz, Daniela; Maity, Gandhari; Perez-Tilve, Diego; Prakash, Sneha; Sanchez-Garrido, Miguel A; Zhang, Qian; Staels, Bart; Krahmer, Natalie; DiMarchi, Richard D; Tschöp, Matthias H; Finan, Brian; Müller, Timo D 2022. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature metabolism, 4 8, 1071-1083Yang, Bin; Gelfanov, Vasily M; El, Kimberley; Chen, Alex; Rohlfs, Rebecca; DuBois, Barent; Kruse Hansen, Ann Maria; Perez-Tilve, Diego; Knerr, Patrick J; D'Alessio, David; Campbell, Jonathan E; Douros, Jonathan D; Finan, Brian 2022. Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems. Molecular metabolism, 66 , 101638Yang, Bin; Gelfanov, Vasily M; Perez-Tilve, Diego; DuBois, Barent; Rohlfs, Rebecca; Levy, Jay; Douros, Jonathan D; Finan, Brian; Mayer, John P; DiMarchi, Richard D 2021. Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists. Journal of medicinal chemistry, 64 8, 4697-4708Zhang, Qian; Delessa, Challa Tenagne; Augustin, Robert; Bakhti, Mostafa; Colldén, Gustav; Drucker, Daniel J; Feuchtinger, Annette; Caceres, Cristina Garcia; Grandl, Gerald; Harger, Alexandra; Herzig, Stephan; Hofmann, Susanna; Holleman, Cassie Lynn; Jastroch, Martin; Keipert, Susanne; Kleinert, Maximilian; Knerr, Patrick J; Kulaj, Konxhe; Legutko, Beata; Lickert, Heiko; Liu, Xue; Luippold, Gerd; Lutter, Dominik; Malogajski, Emilija; Medina, Marta Tarquis; Mowery, Stephanie A; Blutke, Andreas; Perez-Tilve, Diego; Salinno, Ciro; Sehrer, Laura; DiMarchi, Richard D; Tschöp, Matthias H; Stemmer, Kerstin; Finan, Brian; Wolfrum, Christian; Müller, Timo D 2021. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell metabolism, 33 4, 833-844.e5Zizzari, Philippe; He, Rongjun; Falk, Sarah; Bellocchio, Luigi; Allard, Camille; Clark, Samantha; Lesté-Lasserre, Thierry; Marsicano, Giovanni; Clemmensen, Christoffer; Perez-Tilve, Diego; Finan, Brian; Cota, Daniela; Quarta, Carmelo 2021. CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity. Diabetes, 70 2, 415-422Kabotso, Daniel E K; Smiley, David; Mayer, John P; Gelfanov, Vasily M; Perez-Tilve, Diego; DiMarchi, Richard D; Pohl, Nicola L B; Liu, Fa 2020. Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence. Journal of medicinal chemistry, 63 11, 6134-6143Knerr, Patrick J; Mowery, Stephanie A; Finan, Brian; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D 2020. Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates. Peptides, 125 , 170225Pan, Jia; Parlee, Sebastian D; Brunel, Florence M; Li, Pengyun; Lu, Wei; Perez-Tilve, Diego; Liu, Fa; Finan, Brian; Kharitonenkov, Alexei; DiMarchi, Richard D 2020. Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21. ACS pharmacology & translational science, 3 5, 978-986Perez-Tilve, Diego 2020. Glucagon Peptide Family and Adipose Tissue: Not that Intimate, just Acquaintances. Endocrinology, 161 2, Sorrell, Joyce; Yates, Emily; Rivir, Marita; Woods, Stephen C; Hogenesch, John B; Perez-Tilve, Diego 2020. The central melanocortin system mediates the benefits of time-restricted feeding on energy balance. Physiology & behavior, 227 , 113132Brunel, Florence M; Mayer, John P; Gelfanov, Vasily M; Zaykov, Alexander N; Finan, Brian; Perez-Tilve, Diego; DiMarchi, Richard D 2019. A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity. ACS chemical biology, 14 8, 1829-1835Holland, Jenna; Sorrell, Joyce; Yates, Emily; Smith, Kathleen; Arbabi, Shahriar; Arnold, Myrtha; Rivir, Marita; Morano, Rachel; Chen, Jenny; Zhang, Xiang; Dimarchi, Richard; Woods, Stephen C; Sanchez-Gurmaches, Joan; Wohleb, Eric; Perez-Tilve, Diego 2019. A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Cell reports, 27 8, 2399-2410.e6Mroz, Piotr A; Finan, Brian; Gelfanov, Vasily; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D; Perez-Tilve, Diego 2019. Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism. Molecular metabolism, 20 , 51-62Müller, T D; Finan, B; Bloom, S R; D'Alessio, D; Drucker, D J; Flatt, P R; Fritsche, A; Gribble, F; Grill, H J; Habener, J F; Holst, J J; Langhans, W; Meier, J J; Nauck, M A; Perez-Tilve, D; Pocai, A; Reimann, F; Sandoval, D A; Schwartz, T W; Seeley, R J; Stemmer, K; Tang-Christensen, M; Woods, S C; DiMarchi, R D; Tschöp, M H 2019. Glucagon-like peptide 1 (GLP-1). Molecular metabolism, 30 , 72-130Perez-Tilve, Diego 2019. 'Et Tu, Leptin?'. Trends in endocrinology and metabolism: TEM, 30 4, 232-233Zaykov, Alexander N; Gelfanov, Vasily M; Perez-Tilve, Diego; Finan, Brian; DiMarchi, Richard D 2019. Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice. Peptides, 120 , 170116Agrawal, Archita; Parlee, Sebastian; Perez-Tilve, Diego; Li, Pengyun; Pan, Jia; Mroz, Piotr A; Kruse Hansen, Ann Maria; Andersen, Birgitte; Finan, Brian; Kharitonenkov, Alexei; DiMarchi, Richard D 2018. Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. Molecular metabolism, , Kim, Teayoun; Holleman, Cassie L; Nason, Shelly; Arble, Deanna M; Ottaway, Nickki; Chabenne, Joseph; Loyd, Christine; Kim, Jeong-A; Sandoval, Darleen; Drucker, Daniel J; DiMarchi, Richard; Perez-Tilve, Diego; Habegger, Kirk M 2018. Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents. Diabetes, 67 11, 2157-2166Kim, Teayoun; Nason, Shelly; Holleman, Cassie; Pepin, Mark; Wilson, Landon; Berryhill, Taylor F; Wende, Adam R; Steele, Chad; Young, Martin E; Barnes, Stephen; Drucker, Daniel J; Finan, Brian; DiMarchi, Richard; Perez-Tilve, Diego; Tschöp, Matthias; Habegger, Kirk M 2018. Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes, 67 9, 1773-1782Mahbod, Parinaz; Smith, Eric P; Fitzgerald, Maureen E; Morano, Rachel L; Packard, Benjamin A; Ghosal, Sriparna; Scheimann, Jessie R; Perez-Tilve, Diego; Herman, James P; Tong, Jenny 2018. Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice. Endocrinology, 159 1, 388-399Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620Rivero-Gutierrez, Belen; Haller, April; Holland, Jenna; Yates, Emily; Khrisna, Radha; Habegger, Kirk; Dimarchi, Richard; D'Alessio, David; Perez-Tilve, Diego 2018. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Molecular metabolism, 17 , 28-38Ryan, Karen K; Packard, Amy E B; Larson, Karlton R; Stout, Jayna; Fourman, Sarah M; Thompson, Abigail M K; Ludwick, Kristen; Habegger, Kirk M; Stemmer, Kerstin; Itoh, Nobuyuki; Perez-Tilve, Diego; Tschöp, Matthias H; Seeley, Randy J; Ulrich-Lai, Yvonne M 2018. Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21. Endocrinology, 159 1, 400-413Knerr, Patrick J; Finan, Brian; Gelfanov, Vasily; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D 2017. Optimization of peptide-based polyagonists for treatment of diabetes and obesity. Bioorganic & medicinal chemistry, , Perez-Tilve, Diego 2017. Novel Hypothalamic Mechanisms in the Pathophysiological Control of Body Weight and Metabolism. Endocrinology, 158 5, 1085-1094Quarta, Carmelo; Clemmensen, Christoffer; Zhu, Zhimeng; Yang, Bin; Joseph, Sini S; Lutter, Dominik; Yi, Chun-Xia; Graf, Elisabeth; García-Cáceres, Cristina; Legutko, Beata; Fischer, Katrin; Brommage, Robert; Zizzari, Philippe; Franklin, Bernardo S; Krueger, Martin; Koch, Marco; Vettorazzi, Sabine; Li, Pengyun; Hofmann, Susanna M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Lickert, Heiko; Strom, Tim M; Gailus-Durner, Valerie; Bechmann, Ingo; Perez-Tilve, Diego; Tuckermann, Jan; Hrab? de Angelis, Martin; Sandoval, Darleen; Cota, Daniela; Latz, Eicke; Seeley, Randy J; Müller, Timo D; DiMarchi, Richard D; Finan, Brian; Tschöp, Matthias H 2017. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell metabolism, 26 4, 620-632.e6Finan, Brian; Clemmensen, Christoffer; Zhu, Zhimeng; Stemmer, Kerstin; Gauthier, Karine; Müller, Luisa; De Angelis, Meri; Moreth, Kristin; Neff, Frauke; Perez-Tilve, Diego; Fischer, Katrin; Lutter, Dominik; Sánchez-Garrido, Miguel A; Liu, Peng; Tuckermann, Jan; Malehmir, Mohsen; Healy, Marc E; Weber, Achim; Heikenwalder, Mathias; Jastroch, Martin; Kleinert, Maximilian; Jall, Sigrid; Brandt, Sara; Flamant, Frédéric; Schramm, Karl-Werner; Biebermann, Heike; Döring, Yvonne; Weber, Christian; Habegger, Kirk M; Keuper, Michaela; Gelfanov, Vasily; Liu, Fa; Köhrle, Josef; Rozman, Jan; Fuchs, Helmut; Gailus-Durner, Valerie; Hrab? de Angelis, Martin; Hofmann, Susanna M; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard; Müller, Timo D 2016. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell, 167 3, 843-857.e14Finan, Brian; Müller, Timo D; Clemmensen, Christoffer; Perez-Tilve, Diego; DiMarchi, Richard D; Tschöp, Matthias H 2016. Reappraisal of GIP Pharmacology for Metabolic Diseases. Trends in molecular medicine, 22 5, 359-76Kabra, Dhiraj G; Pfuhlmann, Katrin; García-Cáceres, Cristina; Schriever, Sonja C; Casquero García, Veronica; Kebede, Adam Fiseha; Fuente-Martin, Esther; Trivedi, Chitrang; Heppner, Kristy; Uhlenhaut, N Henriette; Legutko, Beata; Kabra, Uma D; Gao, Yuanqing; Yi, Chun-Xia; Quarta, Carmelo; Clemmensen, Christoffer; Finan, Brian; Müller, Timo D; Meyer, Carola W; Paez-Pereda, Marcelo; Stemmer, Kerstin; Woods, Stephen C; Perez-Tilve, Diego; Schneider, Robert; Olson, Eric N; Tschöp, Matthias H; Pfluger, Paul T 2016. Hypothalamic leptin action is mediated by histone deacetylase 5. Nature communications, 7 , 10782Loyd, Christine; Magrisso, I Jack; Haas, Michael; Balusu, Sowmya; Krishna, Radha; Itoh, Nobuyuki; Sandoval, Darleen A; Perez-Tilve, Diego; Obici, Silvana; Habegger, Kirk M 2016. Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding. Journal of applied physiology (Bethesda, Md. : 1985), 121 3, 687-98Mroz, Piotr A; Perez-Tilve, Diego; Liu, Fa; Gelfanov, Vasily; DiMarchi, Richard D; Mayer, John P 2016. Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization. Journal of medicinal chemistry, 59 17, 8061-7Mroz, Piotr A; Perez-Tilve, Diego; Liu, Fa; Mayer, John P; DiMarchi, Richard D 2016. Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon. ACS chemical biology, 11 12, 3412-3420Raab, Susanne; Wang, Haiyan; Uhles, Sabine; Cole, Nadine; Alvarez-Sanchez, Ruben; Künnecke, Basil; Ullmer, Christoph; Matile, Hugues; Bedoucha, Marc; Norcross, Roger D; Ottaway-Parker, Nickki; Perez-Tilve, Diego; Conde Knape, Karin; Tschöp, Matthias H; Hoener, Marius C; Sewing, Sabine 2016. Incretin-like effects of small molecule trace amine-associated receptor 1 agonists. Molecular metabolism, 5 1, 47-56Sánchez-Garrido, Miguel Angel; Habegger, Kirk M; Clemmensen, Christoffer; Holleman, Cassie; Müller, Timo D; Perez-Tilve, Diego; Li, Pengyun; Agrawal, Archita S; Finan, Brian; Drucker, Daniel J; Tschöp, Matthias H; DiMarchi, Richard D; Kharitonenkov, Alexei 2016. Fibroblast activation protein (FAP) as a novel metabolic target. Molecular metabolism, 5 10, 1015-24Tschöp, Matthias H; Finan, Brian; Clemmensen, Christoffer; Gelfanov, Vasily; Perez-Tilve, Diego; Müller, Timo D; DiMarchi, Richard D 2016. Unimolecular Polypharmacy for Treatment of Diabetes and Obesity. Cell metabolism, 24 1, 51-62Arble, Deanna M; Holland, Jenna; Ottaway, Nickki; Sorrell, Joyce; Pressler, Joshua W; Morano, Rachel; Woods, Stephen C; Seeley, Randy J; Herman, James P; Sandoval, Darleen A; Perez-Tilve, Diego 2015. The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology, 156 5, 1685-91Finan, Brian; Yang, Bin; Ottaway, Nickki; Smiley, David L; Ma, Tao; Clemmensen, Christoffer; Chabenne, Joe; Zhang, Lianshan; Habegger, Kirk M; Fischer, Katrin; Campbell, Jonathan E; Sandoval, Darleen; Seeley, Randy J; Bleicher, Konrad; Uhles, Sabine; Riboulet, William; Funk, Jürgen; Hertel, Cornelia; Belli, Sara; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; Drucker, Daniel J; Gelfanov, Vasily; Pfluger, Paul T; Müller, Timo D; Perez-Tilve, Diego; DiMarchi, Richard D; Tschöp, Matthias H 2015. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nature medicine, 21 1, 27-36Heppner, Kristy M; Marks, Sarah; Holland, Jenna; Ottaway, Nickki; Smiley, David; Dimarchi, Richard; Perez-Tilve, Diego 2015. Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice. Diabetologia, 58 9, 2124-32Heppner, Kristy M; Perez-Tilve, Diego 2015. GLP-1 based therapeutics: simultaneously combating T2DM and obesity. Frontiers in neuroscience, 9 , 92Müller, T D; Nogueiras, R; Andermann, M L; Andrews, Z B; Anker, S D; Argente, J; Batterham, R L; Benoit, S C; Bowers, C Y; Broglio, F; Casanueva, F F; D'Alessio, D; Depoortere, I; Geliebter, A; Ghigo, E; Cole, P A; Cowley, M; Cummings, D E; Dagher, A; Diano, S; Dickson, S L; Diéguez, C; Granata, R; Grill, H J; Grove, K; Habegger, K M; Heppner, K; Heiman, M L; Holsen, L; Holst, B; Inui, A; Jansson, J O; Kirchner, H; Korbonits, M; Laferrère, B; LeRoux, C W; Lopez, M; Morin, S; Nakazato, M; Nass, R; Perez-Tilve, D; Pfluger, P T; Schwartz, T W; Seeley, R J; Sleeman, M; Sun, Y; Sussel, L; Tong, J; Thorner, M O; van der Lely, A J; van der Ploeg, L H T; Zigman, J M; Kojima, M; Kangawa, K; Smith, R G; Horvath, T; Tschöp, M H 2015. Ghrelin. Molecular metabolism, 4 6, 437-60Ottaway, Nickki; Mahbod, Parinaz; Rivero, Belen; Norman, Lee Ann; Gertler, Arieh; D'Alessio, David A; Perez-Tilve, Diego 2015. Diet-induced obese mice retain endogenous leptin action. Cell metabolism, 21 6, 877-82Pfluger, Paul T; Kabra, Dhiraj G; Aichler, Michaela; Schriever, Sonja C; Pfuhlmann, Katrin; García, Verónica Casquero; Lehti, Maarit; Weber, Jon; Kutschke, Maria; Rozman, Jan; Elrod, John W; Hevener, Andrea L; Feuchtinger, Annette; Hrab? de Angelis, Martin; Walch, Axel; Rollmann, Stephanie M; Aronow, Bruce J; Müller, Timo D; Perez-Tilve, Diego; Jastroch, Martin; De Luca, Maria; Molkentin, Jeffery D; Tschöp, Matthias H 2015. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell metabolism, 22 5, 838-50Trivedi, Chitrang; Shan, Xiaoye; Tung, Yi-Chun Loraine; Kabra, Dhiraj; Holland, Jenna; Amburgy, Sarah; Heppner, Kristy; Kirchner, Henriette; Yeo, Giles S H; Perez-Tilve, Diego 2015. Tachykinin-1 in the central nervous system regulates adiposity in rodents. Endocrinology, 156 5, 1714-23Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., Garcia-Caceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschop, M. H., and Yi, C. X. 2014. Hormones and diet, but not body weight, control hypothalamic microglial activity Glia , 62, 17-25Gao, Yuanqing; Ottaway, Nickki; Schriever, Sonja C; Legutko, Beata; García-Cáceres, Cristina; de la Fuente, Esther; Mergen, Clarita; Bour, Susanne; Thaler, Joshua P; Seeley, Randy J; Filosa, Jessica; Stern, Javier E; Perez-Tilve, Diego; Schwartz, Michael W; Tschöp, Matthias H; Yi, Chun-Xia 2014. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia, 62 1, 17-25Habegger, K. M., Heppner, K. M., Amburgy, S. E., Ottaway, N., Holland, J., Raver, C., Bartley, E., Muller, T. D., Pfluger, P. T., Berger, J., Toure, M., Benoit, S. C., Dimarchi, R. D., Perez-Tilve, D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. 2014. GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats. Diabetes., 63, 505-13Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; Dimarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2014. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes, 63 2, 505-13Heppner, K. M., Piechowski, C. L., Muller, A.,D. A., and Perez-Tilve, D. Ottaway, N., Sisley, S., Smiley, D. L., Habegger, K. M., Pfluger, P. T., Dimarchi, R., Biebermann, H., Tschop, M. H., Sandoval, 2014. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. 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