Projects

Institutes & Centers / Center for Addiction Research / Projects

Active Projects

#R01DA057944 Title: Role of Prelimbic Cortical Endocannabinoid Signaling in Enhanced Cocaine-seeking Behavior Following Combined Repeated Stress and Cocaine Use in Rats
Start: 03-01-2024 / End: 01-31-2025 Primary Investigators: Jayme Rose McReynolds Grant Sponsor: National Institute on Drug Abuse Grant Amount: $440,054.00

#20-A0-S2-003671 / UG1DA013035 Title: CTN0100 - Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Phramacotherapy (RDD)
Start: 09-01-2020 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Investigators: Winhusen, T John Grant Sponsor: National Institute on Drug Abuse Grant Amount: $194,134.00

#A00-0322-S010 Title: CTN-0107: Peer Recovery Support: A Bridge to Treatment for Overdose Survivors (Study site: Mercy Health, Youngstown, OH)
Start: 03-01-2021 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: Medical University of South Carolina Grant Amount: $100,877.00

#UG1DA013732-00000 Title: The Ohio Valley Node (OVN) of the Clinical Trials Network
Start: 09-01-2015 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Investigators: Brown, Jennifer; Lyons, Michael; Montgomery, LaTrice; Burlew, Kathleen Grant Sponsor: National Institute on Drug Abuse Grant Amount: $16,108,823.00

#UG1DA013732-00035 Title: CTN Base: The Ohio Valley Node (OVN) joined NIDA’s Clinical Trials Network (CTN) in September of 2000 as one of the CTN’s second wave of awardees and has been funded continuously since then. Funds in the current 5-year award cycle (6/1/2020 - 2/28/2025) support OVN infrastructure, project development, and support to all OVN performance sites.
Start: 06-01-2020 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $3,762,933.0

#UG1DA013732-00037 Title: CTN-0080: Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations. (Study sites: Vanderbilt University Medical Center, Nashville, TN; Marshall, Huntington, WV)
Start: 06-01-2018 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $9,157,440.00

#UG1DA013732-00039 Title: CTN-0125: Integrative Data Analysis of CTN Studies to Examine the Impact of Psychosocial Treatments for Black People who use Cocaine (Secondary analysis)
Start: 07-01-2021 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $105,781.00

#UG1DA013732-00040 Title: CTN-0129: “The Great Plains Initiative.”
Start: 03-01-2021 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $770.042.0

#UG1DA013732-00041 Title: CTN-0138: Adaptation and Implementation of a Community Pharmacy-Based Prescription Drug Monitoring Pro-gram Risk Assessment Tool
Start: 03-01-2022 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $1,176,290.0

#UG1DA013732-00042 Title: CTN-0142: Towards personalized medicine in medication for opioid use disorder (MOUD): Analyses of Veterans Health Administration data to delineate patient characteristics associated with treatment outcomes and successful MOUD discontinuation
Start: 03-01-2022 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $610,901.00

#UG1DA013732-00046 Title: CTN-0150: Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME) for pregnant and postpartum persons in MOUD: A pilot randomized trial (TOME trial). (Study sites: Vanderbilt University Medical Center, Nashville, TN; Marshall, Huntington, WV; Magee Women’s Hospital/University of Pittsburgh, Pittsburgh, PA; University of Utah, Salt Lake City, UT; Medical University of South Carolina, Charleston, SC; Gateway Community Services, Inc., Jacksonville, FL)
Start: 03-01-2023 / End: 02-28-2025 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $443,499.00

#UG1DA013732-00046-A-1 Title: CTN-0080-A-1: Successful Recruitment and Retention in a Randomized Controlled Trial of Pregnant People with Opioid Use Disorder (SUCCESS STUDY)
Start: 03-01-2024 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Investigators: Winhusen, T. Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $333,963.00

#UG1DA013732-00046-A-2 Title: CTN-0080-A-2: Promoting Research with Mothers receiving OUD Treatment; a focus on Equity (PRoMOTE)
Start: 03-01-2024 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $298,861.00

#UG1DA013732-00046-A-3 Title: CTN-0080-A-3: Improved Messaging Strategies for MOUD for Underserved Populations of Pregnant and Postpartum Individuals with OUD
Start: 03-01-2024 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $4050.00

#UG1DA013732-00060 Title: CTN-0152: Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the treatment of opioid use disorder: A pragmatic, multi-site, double-blind, Randomized, placebo-controlled, trial (TAB).
Start: 09-15-2024 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $498,507.00

#UG1DA013732-00061 Title: CTN-0153: Effects of Semaglutide and Tirzepatide on Incidence and Outcomes of Stimulant Use Disorders and Opioid Use Disorder in Real-world Populations: Target Trial Emulation Using Patient Electronic Health Records (GLP-SUD).
Start: 09-15-2024 / End: 02-28-2025 Primary Investigators: T. John John Winhusen Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $502,744.00

#60071380 OSU (UM1DA049417 NIH NIDA) Title: Optimizing HEALing in Ohio Communities (OHIO)
Start: 04-17-2019 / End: 03-31-2025 Primary Investigators: T. John John Winhusen Investigators: Winhusen, T John; Brown, Jennifer PhD; Lyons, Michael MD; McMullan, Jason Grant Sponsor: National Institute on Drug Abuse Grant Amount: $15,781,558.00

#312397 / R01DA051895 Title: Role of Siglec-1 in HIV Interactions with Microglia and Astrocytes
Start: 07-15-2020 / End: 04-30-2025 Primary Investigators: Jason T. Blackard Investigators: Blackard, Jason Grant Sponsor: National Institute on Drug Abuse Grant Amount: $10,964.00 (level: Federal)

#K23DA058053 Title: A Unique, Co-designed Family-based Therapy for Marginalized Women with Opioid Use Disorder and Justice-Involvement
Start: 06-15-2023 / End: 05-01-2028 Primary Investigators: Aaron William Murnan Investigators: Aaron Murnan; Melinda Butsch Kovacic; Jennifer Brown; Sarah Manchak; Christine Wilder Grant Sponsor: National Institute on Drug Abuse Grant Amount: $1,000,000 (level: National)

#K01Da054339 Title: Circuit-Selective Astroglial Plasticity During Opioid Relapse
Start: 08-01-2022 / End: 07-31-2027 Primary Investigators: Anna Katherine Kruyer Investigators: Anna Kruyer Grant Sponsor: National Institute on Drug Abuse Grant Amount: $964,010.00 (level: National)

#R01AA030486 Title: Therapeutic and mechanistic significance of altered metabolism of HIV medicines by alcohol- or alcohol/synthetic opioid combination
Start: 09-10-2022 / End: 07-31-2027 Investigators: ; Blackard, Jason; Brown, Jennifer; Robertson, Jaime; Welge, Jeffrey; Yan, Bingfang Grant Sponsor: National Institute on Alcohol Abuse and Alcoholism Grant Amount: $721,672.00 (level: Federal)

#315660 / H79TI084035 Title: FY 2021 Screening, Brief Intervention and Referral to Treatment (SBIRT)
Start: 09-30-2021 / End: 09-29-2026 Primary Investigators: Shauna P Acquavita Investigators: Acquavita, Shauna Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $33,878.00 (level: Federal)

#H79TI085997 Title: Alternatives to opioids for pain in the Emergency Department: Implementing Integrative Health approaches and expanding local nerve block initiatives
Start: 09-30-2023 / End: 09-29-2026 Primary Investigators: Caroline Elizabeth Freiermuth Investigators: Freiermuth, Caroline; Ryan, Richard Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $478,958.00

Recently Completed Projects

#ODMHA 2300761 (SAMHSA H79TI085753) Title: State Opioid and Stimulant Response (SOS) 3.0
Start: 2022-09-30 / End: 2024-09-29 Primary Investigators: Ryan, Richard MD Investigators: Freiermuth, Caroline MD Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $300,000.00 (level: Federal)

#U01DA050330 Title: IND-Enabling Pre-Clinical Studies to Accelerate the Clinical Development of a Humanized Anti-Cocaine Monoclonal Antibody
Start: 2019-09-15 / End: 2024-07-31 Primary Investigators: Norman, Andrew PhD Investigators: Amlal, Hassane PhD; Kirley, Terry PhD; Rubinstein, Jack MD; Webster, Rose Grant Sponsor: National Institute on Drug Abuse Grant Amount: $4,056,896.00 (level: Federal)

#R21AI165171 Title: Biomarkers of Replication and Injury in HBV/HIV Coinfection
Start: 2021-07-12 / End: 2024-06-30 Primary Investigators: Sherman, Kenneth MD,PhD Investigators: Blackard, Jason PhD Grant Sponsor: National Institute of Allergy and Infectious Diseases Grant Amount: $443,976.00 (level: Federal)

#2023-110901 / 6NU38OT000306-05-01 Title: ED Based Substance Use Navigation - Advancing the Evidence
Start: 2023-10-01 / End: 2024-06-30 Primary Investigators: Freiermuth, Caroline MD Investigators: Ryan, Richard MD Grant Sponsor: Centers for Disease Control and Prevention Grant Amount: $99,708.53 (level: Federal)

#R13AI071925 Title: HIV and Liver Disease Conference
Start: 2021-04-12 / End: 2024-03-31 Primary Investigators: Sherman, Kenneth MD,PhD Grant Sponsor: National Institute of Allergy and Infectious Diseases Grant Amount: $65,001.00 (level: Federal)

#T98HP33422 Title: SAFE T 2019 - Opioid Workforce Expansion Program (OWEP)
Start: 2019-09-01 / End: 2023-12-31 Primary Investigators: Brubaker, Michael Investigators: Acquavita, Shauna Grant Sponsor: Health Resources and Services Administration Grant Amount: $1,332,484.78 (level: Federal)

#H79TI080732 Title: ASPIRE: Accelerating Substance use and Psychiatric screening among Individuals at-risk or HIV-infected and facilitated Referral via the Emergency Department
Start: 2018-09-30 / End: 2023-09-29 Primary Investigators: Sprunger, Joel PhD Investigators: Brown, Jennifer PhD; Sprunger, Joel PhD Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $2,447,305.00 (level: Federal)

#5K23DA042130-01A1 Title: Twitter-Based Intervention for Young Adult African American Blunt Smokers
Start: 2017-08-15 / End: 2023-07-31 Primary Investigators: Montgomery, LaTrice PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $726,280.00 (level: Federal)

#R01DA044248 Title: EMPOWER: Evaluating the ability to reduce Morphine equivalent dose for chronic Pain patients receiving Opioid-therapy through a Web-based E-Health self-management program: a Randomized multi-site Clin
Start: 2017-09-01 / End: 2023-06-30 Primary Investigators: Winhusen, T. John PHD Investigators: Elder, Nancy MD; Regan, Saundra PHD; Welge, Jeffrey PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $2,550,410.50 (level: Federal)

#U01DA048525 Title: First-In-Human Study of a Humanized Anti-Cocaine Monoclonal Antibody
Start: 2019-07-01 / End: 2023-04-30 Primary Investigators: Norman, Andrew PhD Investigators: Geracioti, Thomas MD; Kirley, Terry PhD; Nelson, Erik MD; Ridgway, William MD; Webster, Rose ; Welge, Jeffrey PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $8,474,481.00 (level: Federal)

#03140014IN0223 Title: UC Early Intervention Program - Integrated Naloxone Access and Infrastructure (IN23)
Start: 2021-09-30 / End: 2023-03-31 Primary Investigators: Freiermuth, Caroline MD Investigators: Jarrell, Kelli MD Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $93,250.00 (level: Federal)

#Services Agreement / ISR 117-10246 Title: An evaluation of vertical transmission of hepatitis C virus (HCV) and natural history of chronic HCV in pregnant women with subsequent treatment post-partum
Start: 2019-08-01 / End: 2023-01-01 Primary Investigators: Blackard, Jason PhD Grant Sponsor: Gilead Sciences, Inc. Grant Amount: $75,855.00 (level: Industry)