Education/CredentialsCertificate: University of Cincinnati (Clinical Research) Contact Information Medical Sciences Building 5002A Office 513-558-7582 Email hollanjs@ucmail.uc.edu Peer Reviewed Publications Holland, Jenna; Sorrell, Joyce; Yates, Emily; Smith, Kathleen; Arbabi, Shahriar; Arnold, Myrtha; Rivir, Marita; Morano, Rachel; Chen, Jenny; Zhang, Xiang; Dimarchi, Richard; Woods, Stephen C; Sanchez-Gurmaches, Joan; Wohleb, Eric; Perez-Tilve, Diego 2019. A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Cell reports, 27 8, 2399-2410.e6Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620Rivero-Gutierrez, Belen; Haller, April; Holland, Jenna; Yates, Emily; Khrisna, Radha; Habegger, Kirk; Dimarchi, Richard; D'Alessio, David; Perez-Tilve, Diego 2018. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Molecular metabolism, 17 , 28-38Arble, Deanna M; Holland, Jenna; Ottaway, Nickki; Sorrell, Joyce; Pressler, Joshua W; Morano, Rachel; Woods, Stephen C; Seeley, Randy J; Herman, James P; Sandoval, Darleen A; Perez-Tilve, Diego 2015. The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology, 156 5, 1685-91Heppner, Kristy M; Marks, Sarah; Holland, Jenna; Ottaway, Nickki; Smiley, David; Dimarchi, Richard; Perez-Tilve, Diego 2015. Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice. Diabetologia, 58 9, 2124-32Trivedi, Chitrang; Shan, Xiaoye; Tung, Yi-Chun Loraine; Kabra, Dhiraj; Holland, Jenna; Amburgy, Sarah; Heppner, Kristy; Kirchner, Henriette; Yeo, Giles S H; Perez-Tilve, Diego 2015. Tachykinin-1 in the central nervous system regulates adiposity in rodents. Endocrinology, 156 5, 1714-23Habegger, Kirk M; Al-Massadi, Omar; Heppner, Kristy M; Myronovych, Andriy; Holland, Jenna; Berger, Jose; Yi, Chun-Xia; Gao, Yuanging; Lehti, Maarit; Ottaway, Nickki; Amburgy, Sarah; Raver, Christine; Müller, Timo D; Pfluger, Paul T; Kohli, Rohit; Perez-Tilve, Diego; Seeley, Randy J; Tschöp, Matthias H 2014. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut, 63 8, 1238-46Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; Dimarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2014. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes, 63 2, 505-13Finan, Brian; Ma, Tao; Ottaway, Nickki; Müller, Timo D; Habegger, Kirk M; Heppner, Kristy M; Kirchner, Henriette; Holland, Jenna; Hembree, Jazzminn; Raver, Christine; Lockie, Sarah H; Smiley, David L; Gelfanov, Vasily; Yang, Bin; Hofmann, Susanna; Bruemmer, Dennis; Drucker, Daniel J; Pfluger, Paul T; Perez-Tilve, Diego; Gidda, Jaswant; Vignati, Louis; Zhang, Lianshan; Hauptman, Jonathan B; Lau, Michele; Brecheisen, Mathieu; Uhles, Sabine; Riboulet, William; Hainaut, Emmanuelle; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; DiMarchi, Richard D; Tschöp, Matthias H 2013. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Science translational medicine, 5 209, 209ra151Habegger, Kirk M; Kirchner, Henriette; Yi, Chun-Xia; Heppner, Kristy M; Sweeney, Dan; Ottaway, Nickki; Holland, Jenna; Amburgy, Sarah; Raver, Christine; Krishna, Radhakrishna; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Obici, Silvana; DiMarchi, Richard D; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2013. GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes, 62 9, 3261-7Habegger, Kirk M; Stemmer, Kerstin; Cheng, Christine; Müller, Timo D; Heppner, Kristy M; Ottaway, Nickki; Holland, Jenna; Hembree, Jazzminn L; Smiley, David; Gelfanov, Vasily; Krishna, Radha; Arafat, Ayman M; Konkar, Anish; Belli, Sara; Kapps, Martin; Woods, Stephen C; Hofmann, Susanna M; D'Alessio, David; Pfluger, Paul T; Perez-Tilve, Diego; Seeley, Randy J; Konishi, Morichika; Itoh, Nobuyujki; Kharitonenkov, Alexei; Spranger, Joachim; DiMarchi, Richard D; Tschöp, Matthias H 2013. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes, 62 5, 1453-63Kirchner, Henriette; Heppner, Kristy M; Holland, Jenna; Kabra, Dhiraj; Tschöp, Matthias H; Pfluger, Paul T 2013. Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background. PloS one, 8 4, e61822Müller, Timo D; Lee, Sang Jun; Jastroch, Martin; Kabra, Dhiraj; Stemmer, Kerstin; Aichler, Michaela; Abplanalp, Bill; Ananthakrishnan, Gayathri; Bhardwaj, Nakul; Collins, Sheila; Divanovic, Senad; Endele, Max; Finan, Brian; Gao, Yuanqing; Habegger, Kirk M; Hembree, Jazzmin; Heppner, Kristy M; Hofmann, Susanna; Holland, Jenna; Küchler, Daniela; Kutschke, Maria; Krishna, Radha; Lehti, Maarit; Oelkrug, Rebecca; Ottaway, Nickki; Perez-Tilve, Diego; Raver, Christine; Walch, Axel K; Schriever, Sonja C; Speakman, John; Tseng, Yu-Hua; Diaz-Meco, Maria; Pfluger, Paul T; Moscat, Jorge; Tschöp, Matthias H 2013. p62 links ?-adrenergic input to mitochondrial function and thermogenesis. The Journal of clinical investigation, 123 1, 469-78Müller, Timo D; Müller, Anne; Yi, Chun-Xia; Habegger, Kirk M; Meyer, Carola W; Gaylinn, Bruce D; Finan, Brian; Heppner, Kristy; Trivedi, Chitrang; Bielohuby, Maximilian; Abplanalp, William; Meyer, Franziska; Piechowski, Carolin L; Pratzka, Juliane; Stemmer, Kerstin; Holland, Jenna; Hembree, Jazzmin; Bhardwaj, Nakul; Raver, Christine; Ottaway, Nickki; Krishna, Radha; Sah, Renu; Sallee, Floyd R; Woods, Stephen C; Perez-Tilve, Diego; Bidlingmaier, Martin; Thorner, Michael O; Krude, Heiko; Smiley, David; DiMarchi, Richard; Hofmann, Susanna; Pfluger, Paul T; Kleinau, Gunnar; Biebermann, Heike; Tschöp, Matthias H 2013. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature communications, 4 , 1968Bielohuby, Maximilian; Stemmer, Kerstin; Berger, José; Ramisch, Juliane; Smith, Kathleen; Holland, Jenna; Parks, Kenneth; Pfluger, Paul T; Habegger, Kirk M; Tschöp, Matthias H; Seeley, Randy J; Bidlingmaier, Martin 2012. Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats. Obesity surgery, 22 1, 140-51Finan, Brian; Yang, Bin; Ottaway, Nickki; Stemmer, Kerstin; Müller, Timo D; Yi, Chun-Xia; Habegger, Kirk; Schriever, Sonja C; García-Cáceres, Cristina; Kabra, Dhiraj G; Hembree, Jazzminn; Holland, Jenna; Raver, Christine; Seeley, Randy J; Hans, Wolfgang; Irmler, Martin; Beckers, Johannes; de Angelis, Martin Hrab?; Tiano, Joseph P; Mauvais-Jarvis, Franck; Perez-Tilve, Diego; Pfluger, Paul; Zhang, Lianshan; Gelfanov, Vasily; DiMarchi, Richard D; Tschöp, Matthias H 2012. Targeted estrogen delivery reverses the metabolic syndrome. Nature medicine, 18 12, 1847-56Habegger, Kirk M; Matzke, Daniela; Ottaway, Nickki; Hembree, Jazzminn; Holland, Jenna; Raver, Christine; Mansfeld, Johannes; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Lee, Sang Jun; Diaz-Meco, Maria; Moscat, Jorge; Leitges, Michael; Tschöp, Matthias H; Hofmann, Susanna M 2012. Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance. Adipocyte, 1 4, 203-214Müller, Timo D; Sullivan, Lorraine M; Habegger, Kirk; Yi, Chun-Xia; Kabra, Dhiraj; Grant, Erin; Ottaway, Nickki; Krishna, Radha; Holland, Jenna; Hembree, Jazzminn; Perez-Tilve, Diego; Pfluger, Paul T; DeGuzman, Michael J; Siladi, Marc E; Kraynov, Vadim S; Axelrod, Douglas W; DiMarchi, Richard; Pinkstaff, Jason K; Tschöp, Matthias H 2012. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. Journal of peptide science : an official publication of the European Peptide Society, 18 6, 383-93Day, Jonathan W; Ottaway, Nickki; Patterson, James T; Gelfanov, Vasily; Smiley, David; Gidda, Jas; Findeisen, Hannes; Bruemmer, Dennis; Drucker, Daniel J; Chaudhary, Nilika; Holland, Jenna; Hembree, Jazzminn; Abplanalp, William; Grant, Erin; Ruehl, Jennifer; Wilson, Hilary; Kirchner, Henriette; Lockie, Sarah Haas; Hofmann, Susanna; Woods, Stephen C; Nogueiras, Ruben; Pfluger, Paul T; Perez-Tilve, Diego; DiMarchi, Richard; Tschöp, Matthias H 2009. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nature chemical biology, 5 10, 749-57
Peer Reviewed Publications Holland, Jenna; Sorrell, Joyce; Yates, Emily; Smith, Kathleen; Arbabi, Shahriar; Arnold, Myrtha; Rivir, Marita; Morano, Rachel; Chen, Jenny; Zhang, Xiang; Dimarchi, Richard; Woods, Stephen C; Sanchez-Gurmaches, Joan; Wohleb, Eric; Perez-Tilve, Diego 2019. A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Cell reports, 27 8, 2399-2410.e6Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620Rivero-Gutierrez, Belen; Haller, April; Holland, Jenna; Yates, Emily; Khrisna, Radha; Habegger, Kirk; Dimarchi, Richard; D'Alessio, David; Perez-Tilve, Diego 2018. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Molecular metabolism, 17 , 28-38Arble, Deanna M; Holland, Jenna; Ottaway, Nickki; Sorrell, Joyce; Pressler, Joshua W; Morano, Rachel; Woods, Stephen C; Seeley, Randy J; Herman, James P; Sandoval, Darleen A; Perez-Tilve, Diego 2015. The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology, 156 5, 1685-91Heppner, Kristy M; Marks, Sarah; Holland, Jenna; Ottaway, Nickki; Smiley, David; Dimarchi, Richard; Perez-Tilve, Diego 2015. Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice. Diabetologia, 58 9, 2124-32Trivedi, Chitrang; Shan, Xiaoye; Tung, Yi-Chun Loraine; Kabra, Dhiraj; Holland, Jenna; Amburgy, Sarah; Heppner, Kristy; Kirchner, Henriette; Yeo, Giles S H; Perez-Tilve, Diego 2015. Tachykinin-1 in the central nervous system regulates adiposity in rodents. Endocrinology, 156 5, 1714-23Habegger, Kirk M; Al-Massadi, Omar; Heppner, Kristy M; Myronovych, Andriy; Holland, Jenna; Berger, Jose; Yi, Chun-Xia; Gao, Yuanging; Lehti, Maarit; Ottaway, Nickki; Amburgy, Sarah; Raver, Christine; Müller, Timo D; Pfluger, Paul T; Kohli, Rohit; Perez-Tilve, Diego; Seeley, Randy J; Tschöp, Matthias H 2014. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut, 63 8, 1238-46Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; Dimarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2014. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes, 63 2, 505-13Finan, Brian; Ma, Tao; Ottaway, Nickki; Müller, Timo D; Habegger, Kirk M; Heppner, Kristy M; Kirchner, Henriette; Holland, Jenna; Hembree, Jazzminn; Raver, Christine; Lockie, Sarah H; Smiley, David L; Gelfanov, Vasily; Yang, Bin; Hofmann, Susanna; Bruemmer, Dennis; Drucker, Daniel J; Pfluger, Paul T; Perez-Tilve, Diego; Gidda, Jaswant; Vignati, Louis; Zhang, Lianshan; Hauptman, Jonathan B; Lau, Michele; Brecheisen, Mathieu; Uhles, Sabine; Riboulet, William; Hainaut, Emmanuelle; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; DiMarchi, Richard D; Tschöp, Matthias H 2013. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Science translational medicine, 5 209, 209ra151Habegger, Kirk M; Kirchner, Henriette; Yi, Chun-Xia; Heppner, Kristy M; Sweeney, Dan; Ottaway, Nickki; Holland, Jenna; Amburgy, Sarah; Raver, Christine; Krishna, Radhakrishna; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Obici, Silvana; DiMarchi, Richard D; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2013. GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes, 62 9, 3261-7Habegger, Kirk M; Stemmer, Kerstin; Cheng, Christine; Müller, Timo D; Heppner, Kristy M; Ottaway, Nickki; Holland, Jenna; Hembree, Jazzminn L; Smiley, David; Gelfanov, Vasily; Krishna, Radha; Arafat, Ayman M; Konkar, Anish; Belli, Sara; Kapps, Martin; Woods, Stephen C; Hofmann, Susanna M; D'Alessio, David; Pfluger, Paul T; Perez-Tilve, Diego; Seeley, Randy J; Konishi, Morichika; Itoh, Nobuyujki; Kharitonenkov, Alexei; Spranger, Joachim; DiMarchi, Richard D; Tschöp, Matthias H 2013. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes, 62 5, 1453-63Kirchner, Henriette; Heppner, Kristy M; Holland, Jenna; Kabra, Dhiraj; Tschöp, Matthias H; Pfluger, Paul T 2013. Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background. PloS one, 8 4, e61822Müller, Timo D; Lee, Sang Jun; Jastroch, Martin; Kabra, Dhiraj; Stemmer, Kerstin; Aichler, Michaela; Abplanalp, Bill; Ananthakrishnan, Gayathri; Bhardwaj, Nakul; Collins, Sheila; Divanovic, Senad; Endele, Max; Finan, Brian; Gao, Yuanqing; Habegger, Kirk M; Hembree, Jazzmin; Heppner, Kristy M; Hofmann, Susanna; Holland, Jenna; Küchler, Daniela; Kutschke, Maria; Krishna, Radha; Lehti, Maarit; Oelkrug, Rebecca; Ottaway, Nickki; Perez-Tilve, Diego; Raver, Christine; Walch, Axel K; Schriever, Sonja C; Speakman, John; Tseng, Yu-Hua; Diaz-Meco, Maria; Pfluger, Paul T; Moscat, Jorge; Tschöp, Matthias H 2013. p62 links ?-adrenergic input to mitochondrial function and thermogenesis. The Journal of clinical investigation, 123 1, 469-78Müller, Timo D; Müller, Anne; Yi, Chun-Xia; Habegger, Kirk M; Meyer, Carola W; Gaylinn, Bruce D; Finan, Brian; Heppner, Kristy; Trivedi, Chitrang; Bielohuby, Maximilian; Abplanalp, William; Meyer, Franziska; Piechowski, Carolin L; Pratzka, Juliane; Stemmer, Kerstin; Holland, Jenna; Hembree, Jazzmin; Bhardwaj, Nakul; Raver, Christine; Ottaway, Nickki; Krishna, Radha; Sah, Renu; Sallee, Floyd R; Woods, Stephen C; Perez-Tilve, Diego; Bidlingmaier, Martin; Thorner, Michael O; Krude, Heiko; Smiley, David; DiMarchi, Richard; Hofmann, Susanna; Pfluger, Paul T; Kleinau, Gunnar; Biebermann, Heike; Tschöp, Matthias H 2013. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature communications, 4 , 1968Bielohuby, Maximilian; Stemmer, Kerstin; Berger, José; Ramisch, Juliane; Smith, Kathleen; Holland, Jenna; Parks, Kenneth; Pfluger, Paul T; Habegger, Kirk M; Tschöp, Matthias H; Seeley, Randy J; Bidlingmaier, Martin 2012. Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats. Obesity surgery, 22 1, 140-51Finan, Brian; Yang, Bin; Ottaway, Nickki; Stemmer, Kerstin; Müller, Timo D; Yi, Chun-Xia; Habegger, Kirk; Schriever, Sonja C; García-Cáceres, Cristina; Kabra, Dhiraj G; Hembree, Jazzminn; Holland, Jenna; Raver, Christine; Seeley, Randy J; Hans, Wolfgang; Irmler, Martin; Beckers, Johannes; de Angelis, Martin Hrab?; Tiano, Joseph P; Mauvais-Jarvis, Franck; Perez-Tilve, Diego; Pfluger, Paul; Zhang, Lianshan; Gelfanov, Vasily; DiMarchi, Richard D; Tschöp, Matthias H 2012. Targeted estrogen delivery reverses the metabolic syndrome. Nature medicine, 18 12, 1847-56Habegger, Kirk M; Matzke, Daniela; Ottaway, Nickki; Hembree, Jazzminn; Holland, Jenna; Raver, Christine; Mansfeld, Johannes; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Lee, Sang Jun; Diaz-Meco, Maria; Moscat, Jorge; Leitges, Michael; Tschöp, Matthias H; Hofmann, Susanna M 2012. Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance. Adipocyte, 1 4, 203-214Müller, Timo D; Sullivan, Lorraine M; Habegger, Kirk; Yi, Chun-Xia; Kabra, Dhiraj; Grant, Erin; Ottaway, Nickki; Krishna, Radha; Holland, Jenna; Hembree, Jazzminn; Perez-Tilve, Diego; Pfluger, Paul T; DeGuzman, Michael J; Siladi, Marc E; Kraynov, Vadim S; Axelrod, Douglas W; DiMarchi, Richard; Pinkstaff, Jason K; Tschöp, Matthias H 2012. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. Journal of peptide science : an official publication of the European Peptide Society, 18 6, 383-93Day, Jonathan W; Ottaway, Nickki; Patterson, James T; Gelfanov, Vasily; Smiley, David; Gidda, Jas; Findeisen, Hannes; Bruemmer, Dennis; Drucker, Daniel J; Chaudhary, Nilika; Holland, Jenna; Hembree, Jazzminn; Abplanalp, William; Grant, Erin; Ruehl, Jennifer; Wilson, Hilary; Kirchner, Henriette; Lockie, Sarah Haas; Hofmann, Susanna; Woods, Stephen C; Nogueiras, Ruben; Pfluger, Paul T; Perez-Tilve, Diego; DiMarchi, Richard; Tschöp, Matthias H 2009. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nature chemical biology, 5 10, 749-57
Holland, Jenna; Sorrell, Joyce; Yates, Emily; Smith, Kathleen; Arbabi, Shahriar; Arnold, Myrtha; Rivir, Marita; Morano, Rachel; Chen, Jenny; Zhang, Xiang; Dimarchi, Richard; Woods, Stephen C; Sanchez-Gurmaches, Joan; Wohleb, Eric; Perez-Tilve, Diego 2019. A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Cell reports, 27 8, 2399-2410.e6Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620Rivero-Gutierrez, Belen; Haller, April; Holland, Jenna; Yates, Emily; Khrisna, Radha; Habegger, Kirk; Dimarchi, Richard; D'Alessio, David; Perez-Tilve, Diego 2018. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Molecular metabolism, 17 , 28-38Arble, Deanna M; Holland, Jenna; Ottaway, Nickki; Sorrell, Joyce; Pressler, Joshua W; Morano, Rachel; Woods, Stephen C; Seeley, Randy J; Herman, James P; Sandoval, Darleen A; Perez-Tilve, Diego 2015. The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology, 156 5, 1685-91Heppner, Kristy M; Marks, Sarah; Holland, Jenna; Ottaway, Nickki; Smiley, David; Dimarchi, Richard; Perez-Tilve, Diego 2015. Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice. Diabetologia, 58 9, 2124-32Trivedi, Chitrang; Shan, Xiaoye; Tung, Yi-Chun Loraine; Kabra, Dhiraj; Holland, Jenna; Amburgy, Sarah; Heppner, Kristy; Kirchner, Henriette; Yeo, Giles S H; Perez-Tilve, Diego 2015. Tachykinin-1 in the central nervous system regulates adiposity in rodents. Endocrinology, 156 5, 1714-23Habegger, Kirk M; Al-Massadi, Omar; Heppner, Kristy M; Myronovych, Andriy; Holland, Jenna; Berger, Jose; Yi, Chun-Xia; Gao, Yuanging; Lehti, Maarit; Ottaway, Nickki; Amburgy, Sarah; Raver, Christine; Müller, Timo D; Pfluger, Paul T; Kohli, Rohit; Perez-Tilve, Diego; Seeley, Randy J; Tschöp, Matthias H 2014. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut, 63 8, 1238-46Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; Dimarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2014. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes, 63 2, 505-13Finan, Brian; Ma, Tao; Ottaway, Nickki; Müller, Timo D; Habegger, Kirk M; Heppner, Kristy M; Kirchner, Henriette; Holland, Jenna; Hembree, Jazzminn; Raver, Christine; Lockie, Sarah H; Smiley, David L; Gelfanov, Vasily; Yang, Bin; Hofmann, Susanna; Bruemmer, Dennis; Drucker, Daniel J; Pfluger, Paul T; Perez-Tilve, Diego; Gidda, Jaswant; Vignati, Louis; Zhang, Lianshan; Hauptman, Jonathan B; Lau, Michele; Brecheisen, Mathieu; Uhles, Sabine; Riboulet, William; Hainaut, Emmanuelle; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; DiMarchi, Richard D; Tschöp, Matthias H 2013. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Science translational medicine, 5 209, 209ra151Habegger, Kirk M; Kirchner, Henriette; Yi, Chun-Xia; Heppner, Kristy M; Sweeney, Dan; Ottaway, Nickki; Holland, Jenna; Amburgy, Sarah; Raver, Christine; Krishna, Radhakrishna; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Obici, Silvana; DiMarchi, Richard D; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H 2013. GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes, 62 9, 3261-7Habegger, Kirk M; Stemmer, Kerstin; Cheng, Christine; Müller, Timo D; Heppner, Kristy M; Ottaway, Nickki; Holland, Jenna; Hembree, Jazzminn L; Smiley, David; Gelfanov, Vasily; Krishna, Radha; Arafat, Ayman M; Konkar, Anish; Belli, Sara; Kapps, Martin; Woods, Stephen C; Hofmann, Susanna M; D'Alessio, David; Pfluger, Paul T; Perez-Tilve, Diego; Seeley, Randy J; Konishi, Morichika; Itoh, Nobuyujki; Kharitonenkov, Alexei; Spranger, Joachim; DiMarchi, Richard D; Tschöp, Matthias H 2013. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes, 62 5, 1453-63Kirchner, Henriette; Heppner, Kristy M; Holland, Jenna; Kabra, Dhiraj; Tschöp, Matthias H; Pfluger, Paul T 2013. Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background. PloS one, 8 4, e61822Müller, Timo D; Lee, Sang Jun; Jastroch, Martin; Kabra, Dhiraj; Stemmer, Kerstin; Aichler, Michaela; Abplanalp, Bill; Ananthakrishnan, Gayathri; Bhardwaj, Nakul; Collins, Sheila; Divanovic, Senad; Endele, Max; Finan, Brian; Gao, Yuanqing; Habegger, Kirk M; Hembree, Jazzmin; Heppner, Kristy M; Hofmann, Susanna; Holland, Jenna; Küchler, Daniela; Kutschke, Maria; Krishna, Radha; Lehti, Maarit; Oelkrug, Rebecca; Ottaway, Nickki; Perez-Tilve, Diego; Raver, Christine; Walch, Axel K; Schriever, Sonja C; Speakman, John; Tseng, Yu-Hua; Diaz-Meco, Maria; Pfluger, Paul T; Moscat, Jorge; Tschöp, Matthias H 2013. p62 links ?-adrenergic input to mitochondrial function and thermogenesis. 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