Amar Natarajan

Azadmanesh, Jahaun; Slobodnik, Katelyn; Struble, Lucas R; Lovelace, Jeffrey J; Cone, Erika A; Dasgupta, Medhanjali; Lutz, William E; Kumar, Siddhartha; Natarajan, Amarnath; Coates, Leighton; Weiss, Kevin L; Myles, Dean A A; Kroll, Thomas; Borgstahl, Gloria E O 2025. The role of Tyr34 in proton coupled electron transfer and product inhibition of manganese superoxide dismutase. Nature communications, 16 1, 1887

Boghean, Lidia; Singh, Sarbjit; Mangalaparthi, Kiran K; Kizhake, Smitha; Umeta, Lelisse; Wishka, Donn; Grothaus, Paul; Pandey, Akhilesh; Natarajan, Amarnath 2025. A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network. Molecules (Basel, Switzerland), 30 9,

Mallareddy, Jayapal Reddy; Yang, Lin; Lin, Wan-Hsin; Feathers, Ryan; Ayers-Ringler, Jennifer; Tolosa, Ezequiel; Kizhake, Amritha G; Kizhake, Smitha; Kubica, Sydney P; Boghean, Lidia; Alvarez, Sophie; Naldrett, Michael J; Singh, Sarbjit; Rana, Sandeep; Zahid, Muhammad; Schaefer-Klein, Janet; Roden, Anja; Kosari, Farhad; Anastasiadis, Panos Z; Borad, Mitesh; Natarajan, Amarnath; Mansfield, Aaron S 2025. Fluorescence based live cell imaging identifies exon 14 skipped hepatocyte growth factor receptor (MET) degraders. RSC advances, 15 13, 10419-10425

Eiken, Alexandria P; Smith, Audrey L; Skupa, Sydney A; Schmitz, Elizabeth; Rana, Sandeep; Singh, Sarbjit; Kumar, Siddhartha; Mallareddy, Jayapal Reddy; de Cubas, Aguirre A; Krishna, Akshay; Kalluchi, Achyuth; Rowley, M Jordan; D'Angelo, Christopher R; Lunning, Matthew A; Bociek, R Gregory; Vose, Julie M; Natarajan, Amarnath; El-Gamal, Dalia 2024. Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects. Cancer research communications, 4 5, 1328-1343

Mukthapuram, Prathap Reddy; Natarajan, Amarnath 2024. Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates. Molecules (Basel, Switzerland), 29 15,

Murthy, Divya; Attri, Kuldeep S; Shukla, Surendra K; Thakur, Ravi; Chaika, Nina V; He, Chunbo; Wang, Dezhen; Jha, Kanupriya; Dasgupta, Aneesha; King, Ryan J; Mulder, Scott E; Souchek, Joshua; Gebregiworgis, Teklab; Rai, Vikant; Patel, Rohit; Hu, Tuo; Rana, Sandeep; Kollala, Sai Sundeep; Pacheco, Camila; Grandgenett, Paul M; Yu, Fang; Kumar, Vikas; Lazenby, Audrey J; Black, Adrian R; Ulhannan, Susanna; Jain, Ajay; Edil, Barish H; Klinkebiel, David L; Powers, Robert; Natarajan, Amarnath; Hollingsworth, Michael A; Mehla, Kamiya; Ly, Quan; Chaudhary, Sarika; Hwang, Rosa F; Wellen, Kathryn E; Singh, Pankaj K 2024. Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nature cell biology, 26 4, 613-627

Tolosa, Ezequiel J; Yang, Lin; Ayers-Ringler, Jennifer; Suzuki, Shinichiro; Mallareddy, Jayapal Reddy; Schaefer-Klein, Janet; Borad, Mitesh; Kosari, Farhad; Natarajan, Amarnath; Mansfield, Aaron S 2024. Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors. Communications biology, 7 1, 1719

Wallin, Savanna; Singh, Sarbjit; Borgstahl, Gloria E O; Natarajan, Amarnath 2023. Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies. Bioorganic & medicinal chemistry letters, 94 , 129465

Gupta, Priyanka; Strange, Keehn; Telange, Rahul; Guo, Ailan; Hatch, Heather; Sobh, Amin; Elie, Jonathan; Carter, Angela M; Totenhagen, John; Tan, Chunfeng; Sonawane, Yogesh A; Neuzil, Jiri; Natarajan, Amarnath; Ovens, Ashley J; Oakhill, Jonathan S; Wiederhold, Thorsten; Pacak, Karel; Ghayee, Hans K; Meijer, Laurent; Reddy, Sushanth; Bibb, James A 2022. Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer. Cell reports, 40 7, 111218

Kour, Smit; Rana, Sandeep; Kizhake, Smitha; Lagundžin, Dragana; Klinkebiel, David; Mallareddy, Jayapal Reddy; Huxford, Tom; Woods, Nicholas T; Natarajan, Amarnath 2022. Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA. RSC chemical biology, 3 1, 32-36

Kour, Smit; Rana, Sandeep; Kubica, Sydney P; Kizhake, Smitha; Ahmad, Mudassier; Muñoz-Trujillo, Catalina; Klinkebiel, David; Singh, Sarbjit; Mallareddy, Jayapal Reddy; Chandra, Surabhi; Woods, Nicholas T; Karpf, Adam R; Natarajan, Amarnath 2022. Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells. The Journal of biological chemistry, 298 5, 101890

Mallareddy, Jayapal Reddy; Singh, Sarbjit; Boghean, Lidia; Natarajan, Amarnath 2022. Selective CDK9 degradation using a proteolysis-targeting chimera (PROTAC) strategy. Future medicinal chemistry, 14 3, 131-134

Napoleon, John Victor; Sagar, Satish; Kubica, Sydney P; Boghean, Lidia; Kour, Smit; King, Hannah M; Sonawane, Yogesh A; Crawford, Ayrianne J; Gautam, Nagsen; Kizhake, Smitha; Bialk, Pawel A; Kmiec, Eric; Mallareddy, Jayapal Reddy; Patil, Prathamesh P; Rana, Sandeep; Singh, Sarbjit; Prahlad, Janani; Grandgenett, Paul M; Borgstahl, Gloria E O; Ghosal, Gargi; Alnouti, Yazen; Hollingsworth, Michael A; Radhakrishnan, Prakash; Natarajan, Amarnath 2022. Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth. Proceedings of the National Academy of Sciences of the United States of America, 119 18, e2115071119

Rana, Sandeep; Kour, Smit; Kizhake, Smitha; King, Hannah M; Mallareddy, Jayapal Reddy; Case, Adam J; Huxford, Tom; Natarajan, Amarnath 2022. Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents. Bioorganic & medicinal chemistry letters, 65 , 128713

King, Hannah M; Rana, Sandeep; Kubica, Sydney P; Mallareddy, Jayapal Reddy; Kizhake, Smitha; Ezell, Edward L; Zahid, Muhammad; Naldrett, Michael J; Alvarez, Sophie; Law, Henry C-H; Woods, Nicholas T; Natarajan, Amarnath 2021. Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax. Bioorganic & medicinal chemistry letters, 43 , 128061

Napoleon, John V; Singh, Sarbjit; Rana, Sandeep; Bendjennat, Mourad; Kumar, Vikas; Kizhake, Smitha; Palermo, Nicholas Y; Ouellette, Michel M; Huxford, Tom; Natarajan, Amarnath 2021. Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner. Chemical communications (Cambridge, England), 57 38, 4678-4681

Rana, Sandeep; Mallareddy, Jayapal Reddy; Singh, Sarbjit; Boghean, Lidia; Natarajan, Amarnath 2021. Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase. Cancers, 13 21,

Rana, Sandeep; Natarajan, Amarnath 2021. Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation. Signal transduction and targeted therapy, 6 1, 142

Sagar, Satish; Singh, Sarbjit; Mallareddy, Jayapal Reddy; Sonawane, Yogesh A; Napoleon, John V; Rana, Sandeep; Contreras, Jacob I; Rajesh, Christabelle; Ezell, Edward L; Kizhake, Smitha; Garrison, Jered C; Radhakrishnan, Prakash; Natarajan, Amarnath 2021. Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy. European journal of medicinal chemistry, 222 , 113579

Rana, Sandeep; Kour, Smit; Sonawane, Yogesh A; Robb, Caroline M; Contreras, Jacob I; Kizhake, Smitha; Zahid, Muhammad; Karpf, Adam R; Natarajan, Amarnath 2020. Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK. Chemical biology & drug design, 96 2, 773-784

Kour, Smit; Rana, Sandeep; Contreras, Jacob I; King, Hannah M; Robb, Caroline M; Sonawane, Yogesh A; Bendjennat, Mourad; Crawford, Ayrianne J; Barger, Carter J; Kizhake, Smitha; Luo, Xu; Hollingsworth, Michael A; Natarajan, Amarnath 2019. CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax. Molecular pharmacology, 96 4, 419-429

Nowialis, Pawel; Lopusna, Katarina; Opavska, Jana; Haney, Staci L; Abraham, Ajay; Sheng, Peike; Riva, Alberto; Natarajan, Amarnath; Guryanova, Olga; Simpson, Melanie; Hlady, Ryan; Xie, Mingyi; Opavsky, Rene 2019. Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions. Nature communications, 10 1, 4374

Rana, Sandeep; Bendjennat, Mourad; Kour, Smit; King, Hannah M; Kizhake, Smitha; Zahid, Muhammad; Natarajan, Amarnath 2019. Selective degradation of CDK6 by a palbociclib based PROTAC. Bioorganic & medicinal chemistry letters, 29 11, 1375-1379

Zheng, Xiao-Feng; Acharya, Sanket S; Choe, Katherine N; Nikhil, Kumar; Adelmant, Guillaume; Satapathy, Shakti Ranjan; Sharma, Samanta; Viccaro, Keith; Rana, Sandeep; Natarajan, Amarnath; Sicinski, Peter; Marto, Jarrod A; Shah, Kavita; Chowdhury, Dipanjan 2019. A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. Nature communications, 10 1, 4252

Contreras, Jacob I; Robb, Caroline M; King, Hannah M; Baxter, Jared; Crawford, Ayrianne J; Kour, Smit; Kizhake, Smitha; Sonawane, Yogesh A; Rana, Sandeep; Hollingsworth, Michael A; Luo, Xu; Natarajan, Amarnath 2018. Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. ACS chemical biology, 13 5, 1148-1152

Naramura, Mayumi; Natarajan, Amarnath 2018. Mouse Pancreatic Tumor Model Independent of Tumor Suppressor Gene Inactivation. Pancreas, 47 5, e27-e29

Abid, Mohammad; Sonawane, Yogesh A; Contreras, Jacob I; Rana, Sandeep; Natarajan, Amarnath 2017. Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation Protein. Current medicinal chemistry, 24 40, 4488-4514

Arnst, Jamie L; Hein, Ashley L; Taylor, Margaret A; Palermo, Nick Y; Contreras, Jacob I; Sonawane, Yogesh A; Wahl, Andrew O; Ouellette, Michel M; Natarajan, Amarnath; Yan, Ying 2017. Discovery and characterization of small molecule Rac1 inhibitors. Oncotarget, 8 21, 34586-34600

Robb, Caroline M; Contreras, Jacob I; Kour, Smit; Taylor, Margaret A; Abid, Mohammad; Sonawane, Yogesh A; Zahid, Muhammad; Murry, Daryl J; Natarajan, Amarnath; Rana, Sandeep 2017. Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC). Chemical communications (Cambridge, England), 53 54, 7577-7580

Sonawane, Yogesh A; Zhu, Yingmin; Garrison, Jered C; Ezell, Edward L; Zahid, Muhammad; Cheng, Xiaodong; Natarajan, Amarnath 2017. Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors. ACS medicinal chemistry letters, 8 11, 1183-1187

Rana, Sandeep; Blowers, Elizabeth C; Tebbe, Calvin; Contreras, Jacob I; Radhakrishnan, Prakash; Kizhake, Smitha; Zhou, Tian; Rajule, Rajkumar N; Arnst, Jamie L; Munkarah, Adnan R; Rattan, Ramandeep; Natarajan, Amarnath 2016. Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study. Journal of medicinal chemistry, 59 10, 5121-7

Sonawane, Yogesh A; Taylor, Margaret A; Napoleon, John Victor; Rana, Sandeep; Contreras, Jacob I; Natarajan, Amarnath 2016. Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy. Journal of medicinal chemistry, 59 19, 8667-8684

Rana, Sandeep; Blowers, Elizabeth C; Natarajan, Amarnath 2015. Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases. Journal of medicinal chemistry, 58 1, 2-29

Arnst, Jamie L; Davies, Christopher W; Raja, Srikumar M; Das, Chittaranjan; Natarajan, Amarnath 2013. High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity. Analytical biochemistry, 440 1, 71-7

Kumar, Eric A; Chen, Qianyi; Kizhake, Smitha; Kolar, Carol; Kang, Myungshim; Chang, Chia-En A; Borgstahl, Gloria E O; Natarajan, Amarnath 2013. The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides. Scientific reports, 3 , 1639

Radhakrishnan, Prakash; Bryant, Vashti C; Blowers, Elizabeth C; Rajule, Rajkumar N; Gautam, Nagsen; Anwar, Muhammad M; Mohr, Ashley M; Grandgenett, Paul M; Bunt, Stephanie K; Arnst, Jamie L; Lele, Subodh M; Alnouti, Yazen; Hollingsworth, Michael A; Natarajan, Amarnath 2013. Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 19 8, 2025-35

Rana, Sandeep; Natarajan, Amarnath 2013. Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones. Organic & biomolecular chemistry, 11 2, 244-7

Kumar, Eric A; Yuan, Ziyan; Palermo, Nicholas Y; Dong, Lin; Ahmad, Gulzar; Lokesh, G L; Kolar, Carol; Kizhake, Smitha; Borgstahl, Gloria E O; Band, Hamid; Natarajan, Amarnath 2012. Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain. Journal of medicinal chemistry, 55 7, 3583-7

Rajule, Rajkumar; Bryant, Vashti C; Lopez, Hernando; Luo, Xu; Natarajan, Amarnath 2012. Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study. Bioorganic & medicinal chemistry, 20 7, 2227-34

Chen, Qianyi; Bryant, Vashti C; Lopez, Hernando; Kelly, David L; Luo, Xu; Natarajan, Amarnath 2011. 2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study. Bioorganic & medicinal chemistry letters, 21 7, 1929-32

Kumar, Eric A; Charvet, Casey D; Lokesh, G L; Natarajan, Amarnath 2011. High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions. Analytical biochemistry, 411 2, 254-60

Palermo, Nicholas Y; Natarajan, Amarnath 2011. Beyond the frog: the evolution of homology models of human IKKβ. Bioorganic & medicinal chemistry letters, 21 20, 6081-4

Yuan, Ziyan; Kumar, Eric A; Campbell, Stephen J; Palermo, Nicholas Y; Kizhake, Smitha; Mark Glover, J N; Natarajan, Amarnath 2011. Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design. ACS medicinal chemistry letters, 2 10, 764-767

Yuan, Ziyan; Kumar, Eric A; Kizhake, Smitha; Natarajan, Amarnath 2011. Structure-activity relationship studies to probe the phosphoprotein binding site on the carboxy terminal domains of the breast cancer susceptibility gene 1. Journal of medicinal chemistry, 54 12, 4264-8

Lokesh, G L; Muralidhara, B K; Negi, Surendra S; Natarajan, Amarnath 2007. Thermodynamics of phosphopeptide tethering to BRCT: the structural minima for inhibitor design. Journal of the American Chemical Society, 129 35, 10658-9