Publications

1. Guha A, Wang X, Harris RA, Nelson AG, Stepp D, Klaassen Z, Raval P, Cortes J, Coughlin SS, Bogdanov VY, Moore JX, Desai N, Miller DD, Lu XY, Kim HW, Weintraub NL. Obesity and the Bidirectional Risk of Cancer and Cardiovascular Diseases in African Americans: Disparity vs. Ancestry. Front Cardiovasc Med. 2021;8:761488. doi: 10.3389/fcvm.2021.761488. eCollection 2021. Review. PubMed PMID: 34733899; PubMed Central PMCID: PMC8558482.
2. Matiash K, Lewis CS, Bogdanov VY. Functional Characteristics and Regulated Expression of Alternatively Spliced Tissue Factor: An Update. Cancers (Basel). 2021 Sep 16;13(18). doi: 10.3390/cancers13184652. Review. PubMed PMID: 34572880; PubMed Central PMCID: PMC8471299.
3. Lewis CS, Karve A, Matiash K, Stone T, Li J, Wang JK, Versteeg HH, Aronow BJ, Ahmad SA, Desai PB, Bogdanov VY. A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma. Front Oncol. 2021;11:691685. doi: 10.3389/fonc.2021.691685. eCollection 2021. PubMed PMID: 34395257; PubMed Central PMCID: PMC8358774.
4. N'Guessan KF, Davis HW, Chu Z, Vallabhapurapu SD, Lewis CS, Franco RS, Olowokure O, Ahmad SA, Yeh JJ, Bogdanov VY, Qi X. Enhanced Efficacy of Combination of Gemcitabine and Phosphatidylserine-Targeted Nanovesicles against Pancreatic Cancer. Mol Ther. 2020 Aug 5;28(8):1876-1886. doi: 10.1016/j.ymthe.2020.05.013. Epub 2020 Jun 8. PubMed PMID: 32516572; PubMed Central PMCID: PMC7403342.
5. Lewis CS, Bogdanov VY. KLF11 (Krüppel-Like Factor 11) Modulates Arterial Thrombosis. Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):309-310. doi: 10.1161/ATVBAHA.119.312368. PubMed PMID: 30811250; PubMed Central PMCID: PMC6555413.
6. Lewis CS, Elnakat Thomas H, Orr-Asman MA, Green LC, Boody RE, Matiash K, Karve A, Hisada YM, Davis HW, Qi X, Mercer CA, Lucas FV, Aronow BJ, Mackman N, Versteeg HH, Bogdanov VY. mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumors. J Thromb Haemost. 2019 Jan;17(1):169-182. doi: 10.1111/jth.14342. Epub 2018 Dec 25. PubMed PMID: 30472780; PubMed Central PMCID: PMC6345540.
7. Caversaccio NI, Reina Caro MD, Prince R, Müller M, Lewis CS, Bogdanov VY, Dufour JF, Angelillo-Scherrer A. Alternatively spliced tissue factor levels are elevated in the plasma of patients with chronic liver diseases. Eur J Gastroenterol Hepatol. 2018 Dec;30(12):1470-1475. doi: 10.1097/MEG.0000000000001236. PubMed PMID: 30113368.
8. Benson TW, Weintraub NL, Kim HW, Seigler N, Kumar S, Pye J, Horimatsu T, Pellenberg R, Stepp DW, Lucas R, Bogdanov VY, Litwin SE, Brittain JE, Harris RA. A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome. Lab Invest. 2018 Oct;98(10):1300-1310. doi: 10.1038/s41374-018-0038-3. Epub 2018 Mar 23. PubMed PMID: 29572498; PubMed Central PMCID: PMC6342280.
9. Benson TW, Weintraub DS, Crowe M, Yiew NKH, Popoola O, Pillai A, Joseph J, Archer K, Greenway C, Chatterjee TK, Mintz J, Stepp DW, Stansfield BK, Chen W, Brittain J, Bogdanov VY, Gao Y, Wilson JG, Tang Y, Kim HW, Weintraub NL. Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding. Mol Cell Endocrinol. 2018 Sep 15;473:79-88. doi: 10.1016/j.mce.2018.01.006. Epub 2018 Jan 16. PubMed PMID: 29341885; PubMed Central PMCID: PMC6045443.
10. Ünlü B, Bogdanov VY, Versteeg HH. Interplay between alternatively spliced Tissue Factor and full length Tissue Factor in modulating coagulant activity of endothelial cells. Thromb Res. 2017 Aug;156:1-7. doi: 10.1016/j.thromres.2017.05.028. Epub 2017 May 25. PubMed PMID: 28570958; PubMed Central PMCID: PMC5739307.
11. Arderiu G, Espinosa S, Peña E, Crespo J, Aledo R, Bogdanov VY, Badimon L. Tissue factor variants induce monocyte transformation and transdifferentiation into endothelial cell-like cells. J Thromb Haemost. 2017 Aug;15(8):1689-1703. doi: 10.1111/jth.13751. Epub 2017 Jul 10. PubMed PMID: 28585414.
12. Ramchandani D, Unruh D, Lewis CS, Bogdanov VY, Weber GF. Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditions. Lab Invest. 2016 Dec;96(12):1234-1245. doi: 10.1038/labinvest.2016.103. Epub 2016 Oct 10. PubMed PMID: 27721473; PubMed Central PMCID: PMC5121009.
13. Sovershaev TA, Unruh D, Sveinbjørnsson B, Fallon JT, Hansen JB, Bogdanov VY, Sovershaev MA. A novel role of bone morphogenetic protein-7 in the regulation of adhesion and migration of human monocytic cells. Thromb Res. 2016 Nov;147:24-31. doi: 10.1016/j.thromres.2016.09.018. Epub 2016 Sep 17. PubMed PMID: 27669124.
14. Unruh D, Ünlü B, Lewis CS, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Adam M, Van Dreden P, Woodhams BJ, Ramchandani D, Weber GF, Rak JW, Wolberg AS, Mackman N, Versteeg HH, Bogdanov VY. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget. 2016 May 3;7(18):25264-75. doi: 10.18632/oncotarget.7955. PubMed PMID: 26967388; PubMed Central PMCID: PMC5041902.
15. Unruh D, Sagin F, Adam M, Van Dreden P, Woodhams BJ, Hart K, Lindsell CJ, Ahmad SA, Bogdanov VY. Levels of Alternatively Spliced Tissue Factor in the Plasma of Patients with Pancreatic Cancer May Help Predict Aggressive Tumor Phenotype. Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1206-11. doi: 10.1245/s10434-015-4592-2. Epub 2015 May 12. PubMed PMID: 25963480.
16. Unruh D, Srinivasan R, Benson T, Haigh S, Coyle D, Batra N, Keil R, Sturm R, Blanco V, Palascak M, Franco RS, Tong W, Chatterjee T, Hui DY, Davidson WS, Aronow BJ, Kalfa T, Manka D, Peairs A, Blomkalns A, Fulton DJ, Brittain JE, Weintraub NL, Bogdanov VY. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation. 2015 Nov 17;132(20):1898-908. doi: 10.1161/CIRCULATIONAHA.115.017313. Epub 2015 Oct 14. PubMed PMID: 26467254; PubMed Central PMCID: PMC4772773.
17. Bogdanov VY, Versteeg HH. "Soluble Tissue Factor" in the 21st Century: Definitions, Biochemistry, and Pathophysiological Role in Thrombus Formation. Semin Thromb Hemost. 2015 Oct;41(7):700-7. doi: 10.1055/s-0035-1556049. Epub 2015 Sep 26. Review. PubMed PMID: 26408917; PubMed Central PMCID: PMC4827326.
18. Østerud B, Unruh D, Olsen JO, Kirchhofer D, Owens AP 3rd, Bogdanov VY. Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes. J Thromb Haemost. 2015 Sep;13(9):1676-82. doi: 10.1111/jth.13041. Epub 2015 Jul 27. PubMed PMID: 26176663; NIHMSID:NIHMS1005558.
19. Kocatürk B, Tieken C, Vreeken D, Ünlü B, Engels CC, de Kruijf EM, Kuppen PJ, Reitsma PH, Bogdanov VY, Versteeg HH. Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression. J Thromb Haemost. 2015 Sep;13(9):1683-93. doi: 10.1111/jth.13049. Epub 2015 Jul 31. PubMed PMID: 26179105; PubMed Central PMCID: PMC4560996.
20. Sovershaev TA, Egorina EM, Unruh D, Bogdanov VY, Hansen JB, Sovershaev MA. BMP-7 induces TF expression in human monocytes by increasing F3 transcriptional activity. Thromb Res. 2015 Feb;135(2):398-403. doi: 10.1016/j.thromres.2014.11.031. Epub 2014 Dec 5. PubMed PMID: 25533127.
21. Manka D, Chatterjee TK, Stoll LL, Basford JE, Konaniah ES, Srinivasan R, Bogdanov VY, Tang Y, Blomkalns AL, Hui DY, Weintraub NL. Transplanted perivascular adipose tissue accelerates injury-induced neointimal hyperplasia: role of monocyte chemoattractant protein-1. Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1723-30. doi: 10.1161/ATVBAHA.114.303983. Epub 2014 Jun 19. PubMed PMID: 24947528; PubMed Central PMCID: PMC4103955.
22. Davila M, Robles-Carrillo L, Unruh D, Huo Q, Gardiner C, Sargent IL, Adam M, Woodhams BJ, Francis JL, Bogdanov VY, Amirkhosravi A. Microparticle association and heterogeneity of tumor-derived tissue factor in plasma: is it important for coagulation activation?. J Thromb Haemost. 2014 Feb;12(2):186-96. doi: 10.1111/jth.12475. PubMed PMID: 24298933.
23. Yokota N, Zarpellon A, Chakrabarty S, Bogdanov VY, Gruber A, Castellino FJ, Mackman N, Ellies LG, Weiler H, Ruggeri ZM, Ruf W. Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. J Thromb Haemost. 2014 Jan;12(1):71-81. doi: 10.1111/jth.12442. PubMed PMID: 24175924; PubMed Central PMCID: PMC3947224.
24. Unruh D, Turner K, Srinivasan R, Kocatürk B, Qi X, Chu Z, Aronow BJ, Plas DR, Gallo CA, Kalthoff H, Kirchhofer D, Ruf W, Ahmad SA, Lucas FV, Versteeg HH, Bogdanov VY. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. Int J Cancer. 2014 Jan 1;134(1):9-20. doi: 10.1002/ijc.28327. Epub 2013 Jul 27. PubMed PMID: 23754313; PubMed Central PMCID: PMC4122306.
25. Chatterjee TK, Aronow BJ, Tong WS, Manka D, Tang Y, Bogdanov VY, Unruh D, Blomkalns AL, Piegore MG Jr, Weintraub DS, Rudich SM, Kuhel DG, Hui DY, Weintraub NL. Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis. Physiol Genomics. 2013 Aug 15;45(16):697-709. doi: 10.1152/physiolgenomics.00042.2013. Epub 2013 Jun 4. PubMed PMID: 23737535; PubMed Central PMCID: PMC3742916.
26. Kocatürk B, Van den Berg YW, Tieken C, Mieog JS, de Kruijf EM, Engels CC, van der Ent MA, Kuppen PJ, Van de Velde CJ, Ruf W, Reitsma PH, Osanto S, Liefers GJ, Bogdanov VY, Versteeg HH. Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11517-22. doi: 10.1073/pnas.1307100110. Epub 2013 Jun 25. PubMed PMID: 23801760; PubMed Central PMCID: PMC3710867.
27. Ekser B, Lin CC, Long C, Echeverri GJ, Hara H, Ezzelarab M, Bogdanov VY, Stolz DB, Enjyoji K, Robson SC, Ayares D, Dorling A, Cooper DK, Gridelli B. Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation. Transpl Int. 2012 Aug;25(8):882-96. doi: 10.1111/j.1432-2277.2012.01506.x. Epub 2012 May 30. PubMed PMID: 22642260; PubMed Central PMCID: PMC3394909.
28. Godby RC, Van Den Berg YW, Srinivasan R, Sturm R, Hui DY, Konieczny SF, Aronow BJ, Ozhegov E, Ruf W, Versteeg HH, Bogdanov VY. Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models. Mol Med. 2012 Jul 18;18:771-9. doi: 10.2119/molmed.2011.00416. PubMed PMID: 22481268; PubMed Central PMCID: PMC3409277.
29. Wang JG, Geddings JE, Aleman MM, Cardenas JC, Chantrathammachart P, Williams JC, Kirchhofer D, Bogdanov VY, Bach RR, Rak J, Church FC, Wolberg AS, Pawlinski R, Key NS, Yeh JJ, Mackman N. Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood. 2012 Jun 7;119(23):5543-52. doi: 10.1182/blood-2012-01-402156. Epub 2012 Apr 30. PubMed PMID: 22547577; PubMed Central PMCID: PMC3369688.
30. Lingrel JB, Pilcher-Roberts R, Basford JE, Manoharan P, Neumann J, Konaniah ES, Srinivasan R, Bogdanov VY, Hui DY. Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circ Res. 2012 May 11;110(10):1294-302. doi: 10.1161/CIRCRESAHA.112.267310. Epub 2012 Apr 3. PubMed PMID: 22474254; PubMed Central PMCID: PMC3366344.
31. Srinivasan R, Bogdanov VY. Splice variants of Tissue Factor and integrin-mediated signaling. Thromb Res. 2012 May;129 Suppl 2:S34-7. doi: 10.1016/j.thromres.2012.02.027. Epub 2012 Mar 17. Review. PubMed PMID: 22425320.
32. Basavaraj MG, Sovershaev MA, Egorina EM, Gruber FX, Bogdanov VY, Fallon JT, Østerud B, Mathiesen EB, Hansen JB. Circulating monocytes mirror the imbalance in TF and TFPI expression in carotid atherosclerotic plaques with lipid-rich and calcified morphology. Thromb Res. 2012 Apr;129(4):e134-41. doi: 10.1016/j.thromres.2011.11.044. Epub 2011 Dec 15. PubMed PMID: 22178066.
33. Egorina EM, Sovershaev MA, Bogdanov VY, Sovershaev TA, Fallon JT, Seredkina N, Østerud B, Hansen JB. Low thrombogenicity of calcified atherosclerotic plaques is associated with bone morphogenetic protein-2-dependent inhibition of tissue factor expression. Blood Coagul Fibrinolysis. 2011 Dec;22(8):642-50. doi: 10.1097/MBC.0b013e32834a49fd. PubMed PMID: 21897206.
34. Srinivasan R, Ozhegov E, van den Berg YW, Aronow BJ, Franco RS, Palascak MB, Fallon JT, Ruf W, Versteeg HH, Bogdanov VY. Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling. J Thromb Haemost. 2011 Oct;9(10):2087-96. doi: 10.1111/j.1538-7836.2011.04454.x. PubMed PMID: 21812913; PubMed Central PMCID: PMC3292430.
35. Srinivasan R, Bogdanov VY. Alternatively spliced tissue factor: discovery, insights, clinical implications. Front Biosci (Landmark Ed). 2011 Jun 1;16(8):3061-71. doi: 10.2741/3899. Review. PubMed PMID: 21622222.
36. Sovershaev MA, Egorina EM, Bogdanov VY, Seredkina N, Fallon JT, Valkov AY, Østerud B, Hansen JB. Bone morphogenetic protein -7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor. Thromb Res. 2010 Oct;126(4):306-10. doi: 10.1016/j.thromres.2010.06.026. Epub 2010 Jul 24. PubMed PMID: 20656331.
37. Bogdanov VY, Osterud B. Cardiovascular complications of diabetes mellitus: The Tissue Factor perspective. Thromb Res. 2010 Feb;125(2):112-8. doi: 10.1016/j.thromres.2009.06.033. Epub 2009 Jul 31. Review. PubMed PMID: 19647294.
38. Chandradas S, Deikus G, Tardos JG, Bogdanov VY. Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. J Leukoc Biol. 2010 Jan;87(1):147-52. doi: 10.1189/jlb.0409252. Epub 2009 Oct 20. PubMed PMID: 19843576; PubMed Central PMCID: PMC3210563.
39. van den Berg YW, van den Hengel LG, Myers HR, Ayachi O, Jordanova E, Ruf W, Spek CA, Reitsma PH, Bogdanov VY, Versteeg HH. Alternatively spliced tissue factor induces angiogenesis through integrin ligation. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19497-502. doi: 10.1073/pnas.0905325106. Epub 2009 Oct 29. PubMed PMID: 19875693; PubMed Central PMCID: PMC2780792.
40. Bogdanov VY, Cimmino G, Tardos JG, Tunstead JR, Badimon JJ. Assessment of plasma tissue factor activity in patients presenting with coronary artery disease: limitations of a commercial assay. J Thromb Haemost. 2009 May;7(5):894-7. doi: 10.1111/j.1538-7836.2009.03315.x. Epub 2009 Feb 12. PubMed PMID: 19220730.
41. Eisenreich A, Bogdanov VY, Zakrzewicz A, Pries A, Antoniak S, Poller W, Schultheiss HP, Rauch U. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Circ Res. 2009 Mar 13;104(5):589-99. doi: 10.1161/CIRCRESAHA.108.183905. Epub 2009 Jan 22. PubMed PMID: 19168442.
42. Tardos JG, Eisenreich A, Deikus G, Bechhofer DH, Chandradas S, Zafar U, Rauch U, Bogdanov VY. SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells. J Thromb Haemost. 2008 May;6(5):877-84. doi: 10.1111/j.1538-7836.2008.02946.x. Epub 2008 Mar 1. PubMed PMID: 18315555.
43. Szotowski B, Antoniak S, Goldin-Lang P, Tran QV, Pels K, Rosenthal P, Bogdanov VY, Borchert HH, Schultheiss HP, Rauch U. Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells. Cardiovasc Res. 2007 Mar 1;73(4):806-12. doi: 10.1016/j.cardiores.2006.12.018. Epub 2006 Dec 30. PubMed PMID: 17266944.
44. Bogdanov VY. Blood coagulation and alternative pre-mRNA splicing: an overview. Curr Mol Med. 2006 Dec;6(8):859-69. doi: 10.2174/156652406779010821. Review. PubMed PMID: 17168737.
45. Bogdanov VY, Kirk RI, Miller C, Hathcock JJ, Vele S, Gazdoiu M, Nemerson Y, Taubman MB. Identification and characterization of murine alternatively spliced tissue factor. J Thromb Haemost. 2006 Jan;4(1):158-67. doi: 10.1111/j.1538-7836.2005.01680.x. PubMed PMID: 16409465.
46. Szotowski B, Goldin-Lang P, Antoniak S, Bogdanov VY, Pathirana D, Pauschinger M, Dörner A, Kuehl U, Coupland S, Nemerson Y, Hummel M, Poller W, Hetzer R, Schultheiss HP, Rauch U. Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy. J Am Coll Cardiol. 2005 Apr 5;45(7):1081-9. doi: 10.1016/j.jacc.2004.12.061. PubMed PMID: 15808768.
47. Bogdanov VY, Balasubramanian V, Hathcock J, Vele O, Lieb M, Nemerson Y. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med. 2003 Apr;9(4):458-62. doi: 10.1038/nm841. Epub 2003 Mar 24. PubMed PMID: 12652293.
48. Schecter AD, Spirn B, Rossikhina M, Giesen PL, Bogdanov V, Fallon JT, Fisher EA, Schnapp LM, Nemerson Y, Taubman MB. Release of active tissue factor by human arterial smooth muscle cells. Circ Res. 2000 Jul 21;87(2):126-32. doi: 10.1161/01.res.87.2.126. PubMed PMID: 10903996.
49. Bogdanov VY, Poon M, Taubman MB. Platelet-derived growth factor-specific regulation of the JE promoter in rat aortic smooth muscle cells. J Biol Chem. 1998 Sep 18;273(38):24932-8. doi: 10.1074/jbc.273.38.24932. PubMed PMID: 9733800.
50. Taby O, Rosenfield CL, Bogdanov V, Nemerson Y, Taubman MB. Cloning of the rat tissue factor cDNA and promoter: identification of a serum-response region. Thromb Haemost. 1996 Nov;76(5):697-702. PubMed PMID: 8950776.
51. Poon M, Hsu WC, Bogdanov VY, Taubman MB. Secretion of monocyte chemotactic activity by cultured rat aortic smooth muscle cells in response to PDGF is due predominantly to the induction of JE/MCP-1. Am J Pathol. 1996 Jul;149(1):307-17. PubMed PMID: 8686755; PubMed Central PMCID: PMC1865217.